Cardiac tamponade as an independent condition affecting the relationship between the plasma B-type natriuretic peptide levels and cardiac function
Cardiac tamponade as an independent condition affecting the relationship between the plasma B-type natriuretic peptide levels and cardiac function
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心包填塞作为影响血浆B型利钠肽水平与心功能关系的独立病症
DOI：
10.1007/s00380-012-0278-x
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发表时间：
2013
影响因子：
1.5
通讯作者：
M. Yoshimura
中科院分区：
文献类型：
--
作者：
Kosuke Minai;K. Komukai;S. Arase;T. Nagoshi;Seiichiro Matsuo;Kazuo Ogawa;Y. Kayama;K. Inada;Shin;Tomoyuki Takemoto;H. Sekiyama;T. Date;Takayuki Ogawa;I. Taniguchi;M. Yoshimura
血浆B型利钠肽(BNP)受心功能和多种心外因素的微调。因此，血浆BNP水平和心力衰竭严重程度之间的关系有时似乎不一致。本研究旨在探讨心包填塞患者血浆BNP水平及其心包引流后的变化。本研究包括14例接受心包穿刺术的心包填塞患者。恶性心包填塞13例，尿毒症1例。分别于引流前和引流后24~48h测定血浆BNP水平。虽然患者有严重的心力衰竭症状，但其血浆BNP水平在引流前仅为71.2±11.1pg/ml。适当引流后血浆脑钠素水平升高至186.0±22.5pg/ml，较引流前显著升高(P=0.0002)。在心包填塞患者中，血浆BNP水平较低，可能是由于心室舒缩受损，引流后血浆BNP水平显著升高。这项研究证明了影响血浆BNP水平和心功能之间关系的另一种情况。如果血浆BNP水平与心力衰竭的临床体征之间的关系不一致，则应考虑心脏压塞的存在。
Plasma B-type natriuretic peptide (BNP) is finely regulated by the cardiac function and several extracardiac factors. Therefore, the relationship between the plasma BNP levels and the severity of heart failure sometimes seems inconsistent. The purpose of the present study was to investigate the plasma BNP levels in patients with cardiac tamponade and their changes after pericardial drainage. This study included 14 patients with cardiac tamponade who underwent pericardiocentesis. The cardiac tamponade was due to malignant diseases in 13 patients and uremia in 1 patient. The plasma BNP levels were measured before and 24–48 h after drainage. Although the patients reported severe symptoms of heart failure, their plasma BNP levels were only 71.2 ± 11.1 pg/ml before drainage. After appropriate drainage, the plasma BNP levels increased to 186.0 ± 22.5 pg/ml, which was significantly higher than that before drainage (P = 0.0002). In patients with cardiac tamponade, the plasma BNP levels were low, probably because of impaired ventricular stretching, and the levels significantly increased in response to the primary condition after drainage. This study demonstrates an additional condition that affects the relationship between the plasma BNP levels and cardiac function. If inconsistency is seen in the relationship between the plasma BNP levels and clinical signs of heart failure, the presence of cardiac tamponade should therefore be considered.
对心脏压塞的激素反应：尽管心房压力升高，但仍抑制心房钠尿因子的释放。
影响因子：
37.8
作者：
Mancini,GB;McGillem,MJ;Bates,ER;Weder,AB;DeBoe,SF;Grekin,RJ
通讯作者：
Grekin,RJ