Measurements and models of electric fields in the in vivo human brain during transcranial electric stimulation.
Measurements and models of electric fields in the in vivo human brain during transcranial electric stimulation.
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DOI：
10.7554/elife.18834
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发表时间：
2017-02-07
期刊：
影响因子：
7.7
通讯作者：
Parra LC
中科院分区：
文献类型：
--
作者：
Huang Y;Liu AA;Lafon B;Friedman D;Dayan M;Wang X;Bikson M;Doyle WK;Devinsky O;Parra LC
经颅电刺激的目的是通过在头皮上施加微弱的电流来刺激大脑。然而，人类大脑中电场的大小和空间分布是未知的。我们测量了10名癫痫患者的颅内电位，并利用校准的电流模型估计了整个大脑的电场。当以2 mA刺激时，皮层电场达到0.8 V/m，这是动物研究中有效性的下限。当考虑个体全头部解剖结构时，预测的电场幅度与皮质（r = 0.86）和深度（r = 0.88）电极中的记录值相关。准确的模型需要调整文献中报道的组织电导率值，但当纳入白色物质各向异性或不同的颅骨腔室时，准确性没有提高。这是第一项利用人体体内颅内记录验证和校准电流模型的研究，为靶向刺激和解释临床试验提供了坚实的基础。DOI：http://dx.doi.org/10.7554/eLife.18834.001网站
Transcranial electric stimulation aims to stimulate the brain by applying weak electrical currents at the scalp. However, the magnitude and spatial distribution of electric fields in the human brain are unknown. We measured electric potentials intracranially in ten epilepsy patients and estimated electric fields across the entire brain by leveraging calibrated current-flow models. When stimulating at 2 mA, cortical electric fields reach 0.8 V/m, the lower limit of effectiveness in animal studies. When individual whole-head anatomy is considered, the predicted electric field magnitudes correlate with the recorded values in cortical (r = 0.86) and depth (r = 0.88) electrodes. Accurate models require adjustment of tissue conductivity values reported in the literature, but accuracy is not improved when incorporating white matter anisotropy or different skull compartments. This is the first study to validate and calibrate current-flow models with in vivo intracranial recordings in humans, providing a solid foundation to target stimulation and interpret clinical trials. DOI: http://dx.doi.org/10.7554/eLife.18834.001