Learning from the nexus of autoimmunity and cancer.
Learning from the nexus of autoimmunity and cancer.
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DOI：
10.1016/j.immuni.2023.01.022
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发表时间：
2023-02
期刊：
影响因子：
32.4
通讯作者：
D. Mangani;Dandan Yang;A. Anderson
中科院分区：
文献类型：
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作者：
D. Mangani;Dandan Yang;A. Anderson
免疫系统在自身免疫和癌症这两种免疫谱两端的疾病中起着关键作用。自身免疫是由于T细胞对自身的耐受性丧失而产生的，而在癌症中，对转化的自身的免疫力低下无法控制肿瘤生长。阻断保持自身耐受性的途径被用来释放针对许多肿瘤的免疫力;然而，治疗患者中出现的自身免疫样毒性阻碍了广泛的成功。从自身免疫治疗中获得的知识可以用于治疗患者的这些毒性。此外，对T细胞功能障碍如何在癌症中出现的理解可以用来诱导自身反应性T细胞的类似状态。在这里，我们回顾了关于自身免疫和癌症中T细胞反应的已知信息，并强调了我们可以从这两种疾病的联系中学习的方法，以改善免疫疗法的应用，疗效和管理。
The immune system plays critical roles in both autoimmunity and cancer, diseases at opposite ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance against self, while in cancer, poor immunity against transformed self fails to control tumor growth. Blockade of pathways that preserve self-tolerance is being leveraged to unleash immunity against many tumors; however, widespread success is hindered by the autoimmune-like toxicities that arise in treated patients. Knowledge gained from the treatment of autoimmunity can be leveraged to treat these toxicities in patients. Further, the understanding of how T cell dysfunction arises in cancer can be leveraged to induce a similar state in autoreactive T cells. Here, we review what is known about the T cell response in autoimmunity and cancer and highlight ways in which we can learn from the nexus of these two diseases to improve the application, efficacy, and management of immunotherapies.