A follow-up study of workers at a dye and resin manufacturing plant.
A follow-up study of workers at a dye and resin manufacturing plant.
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对染料和树脂制造厂工人的后续研究。
DOI：
10.1097/00043764-198903000-00016
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Philip A. Cole
中科院分区：
文献类型：
--
作者：
E. Delzell;M. Macaluso;Philip A. Cole
从1952年到1985年，对新泽西州一家染料和树脂制造厂雇用的2642名男子进行了观察，并将他们的死亡率与美国白人男子的死亡率进行了比较。这些工人的死亡经历与以前在辛辛那提化工厂工作有关，该化工厂生产或使用联苯胺和-萘胺。2553名从未在辛辛那提化工厂工作过的男子，所有死因加起来的死亡人数少于预期（观察到的317人/预期的402人），观察到的和预期的癌症死亡人数相等（89/89）。89名前辛辛那提化工厂员工患癌症的比例过高（17/8.6,P = 0.02），这是由于膀胱癌（3/0.25,P = 0.004）、肾癌（2/0.21,P = 0.04）和中枢神经系统癌（2/0.22,P = 0.04）的死亡率增加所致。在新泽西工厂的某些工作区域工作的男性中，癌症发病率也有所上升。其中维修工人的肺癌（18/9.2,P = 0.01）和肝癌（3/0.46,P = 0.02）死亡率升高，偶氮染料工人的胃癌（3/0.40,P = 0.02）和中枢神经系统癌（3/0.44,P = 0.02）死亡率升高，环氧氯丙烷工人的肺癌（4/0.91,P = 0.03）死亡率升高。维修工人的肺癌发病率随着工作时间的延长而增加，这表明与一种未知的职业暴露有关。其他的关联是基于少量的死亡，它们的解释并不清楚。
A total of 2642 men employed at a dye and resin manufacturing plant in New Jersey were observed from the opening of the plant in 1952 through 1985, and their mortality rates were compared with the rates of United States white men. The workers' mortality experience was related to former employment at the Cincinnati Chemical Works, which had produced or used benzidine and beta-naphthylamine. The 2553 men who had never worked at the Cincinnati Chemical Works had fewer than expected deaths from all causes combined (317 observed/402 expected) and equal numbers of observed and expected cancer deaths (89/89). The 89 former Cincinnati Chemical Works employees had an excess of cancer (17/8.6, P = .02), which was due to increased mortality from bladder (3/0.25, P = .004), kidney (2/0.21, P = .04), and CNS (2/0.22, P = .04) cancer. There also were several increases in cancers among men employed in certain work areas at the New Jersey plant. These included elevated mortality from lung (18/9.2, P = .01) and liver (3/0.46, P = .02) cancer among maintenance workers, from stomach (3/0.40, P = .02) and CNS (3/0.44, P = .02) cancer among azo dye workers, and from lung cancer (4/0.91, P = .03) among epichlorohydrin workers. The lung cancer excess among maintenance workers increased with length of employment, suggesting an association with an unidentified occupational exposure. Other associations were based on small numbers of deaths, and their interpretation is not clear.