Impact of stalling events on microcirculatory hemodynamics in the aged brain.
Impact of stalling events on microcirculatory hemodynamics in the aged brain.
复制标题
失速事件对老年大脑微循环血流动力学的影响。
DOI：
10.1111/micc.12845
复制
发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Linninger,AndreasA
中科院分区：
文献类型：
--
作者：
Jamshidi,Mohammad;Ventimiglia,Thomas;Sudres,Patrice;Zhang,Cong;Lesage,Frédéric;Rooney,William;Schwartz,Daniel;Linninger,AndreasA
目的通过观察脑皮层组织氧合对血流的影响，探讨脑微血管在认知功能障碍中的作用。本文研究了皮层血管结构中毛细血管停步对血流和红细胞压积（Ht）等微循环特性的影响。方法使用确定性数学模型模拟真实小鼠皮质的血流，计算血液动力学参数，包括压力、流量、血管直径可调节的红细胞压积和传递时间作为失速事件的函数。结果利用非线性等离子体撇取模型，观察到Ht随皮质深度的增加而增加。沿血管网络的Ht分布迟滞的发生率表明，阻塞部位附近组织周围的红细胞减少，阻塞点下游的Ht浓度降低。在闭塞的上游，Ht明显升高，血液黏稠度增高，导致血流阻力增大。我们预测了由于失速导致的运输时间行为的显著变化，这与在小鼠体内观察到的趋势相匹配。结论这些血细胞数量和质量的变化可能与阿尔茨海默病的发生发展有关，并有助于疾病的发展。
ObjectiveThe role of cerebral microvasculature in cognitive dysfunction can be investigated by identifying the impact of blood flow on cortical tissue oxygenation. In this paper, the impact of capillary stalls on microcirculatory characteristics such as flow and hematocrit (Ht) in the cortical angioarchitecture is studied.MethodsUsing a deterministic mathematical model to simulate blood flow in a realistic mouse cortex, hemodynamics parameters, including pressure, flow, vessel diameter‐adjustable hematocrit, and transit time are calculated as a function of stalling events.ResultsUsing a non‐linear plasma skimming model, it is observed that Ht increases in the penetrating arteries from the pial vessels as a function of cortical depth. The incidence of stalling on Ht distribution along the blood network vessels shows reduction of RBCs around the tissue near occlusion sites and decreased Ht concentration downstream from the blockage points. Moreover, upstream of the occlusion, there is a noticeable increase of the Ht, leading to larger flow resistance due to higher blood viscosity. We predicted marked changes in transit time behavior due to stalls which match trends observed in mice in vivo.ConclusionsThese changes to blood cell quantity and quality may be implicated in the development of Alzheimer's disease and contribute to the course of the illness.