Birth and migration of neurons in the central posterior/prepacemaker nucleus during adulthood in weakly electric knifefish (Eigenmannia sp.).
Birth and migration of neurons in the central posterior/prepacemaker nucleus during adulthood in weakly electric knifefish (Eigenmannia sp.).
复制标题
弱电刀鱼（Eigenmannia sp.）成年期间中央后核/前起搏核神经元的出生和迁移。
DOI：
10.1073/pnas.89.20.9539
复制
发表时间：
1992
影响因子：
11.1
通讯作者：
Zupanc,MM
中科院分区：
文献类型：
--
作者：
Zupanc,GK;Zupanc,MM
与哺乳动物相比，鱼类即使在成年期也能维持其在中枢神经系统中产生神经元的能力。采用免疫组织化学、放射自显影和电镜技术，我们研究了刀鱼（Eigenmannia sp.）中央后/前起搏核复合体（CP/PPn）内的这种生后神经发生，一种弱电硬骨鱼。CP/PPn是丘脑中的双侧神经元簇。它控制着电器官放电的频率调制，因为它们在社会交往中使用。在邻近第三脑室壁的CP/PPn区域（“脑室区”）中，细胞以高速率连续出生。它们在分化成神经元之前经历多次细胞分裂。伴随着这种发展，新生的神经元迁移到CP/PPn的外侧区域。在这一侧向迁移的过程中，他们似乎获得免疫和形态学特征是典型的成熟CP/PPn神经元。我们假设，至少有一些新产生的细胞最终发育成功能性CP/PPn神经元。
In contrast to mammals, fish maintain their capacity to generate neurons in the central nervous system even during adulthood for prolonged periods of life. By employing immunohistochemical, autoradiographic, and electron microscopic techniques, we studied such a postnatal neurogenesis within the complex of the central posterior/prepacemaker nucleus (CP/PPn) in knifefish (Eigenmannia sp.), a weakly electric teleost. The CP/PPn is a bilateral cluster of neurons in the thalamus. It controls frequency modulations of the electric organ discharge as they are used during social interactions. In the CP/PPn region adjacent to the wall of the third ventricle ("ventricular zone"), cells are born continuously and at high rates. They undergo multiple cell divisions before differentiating into neurons. Concomitant with this development, the newborn neurons migrate toward lateral regions of the CP/PPn. In the course of this lateral migration, they appear to acquire immunological and morphological characteristics that are typical for mature CP/PPn neurons. We hypothesize that at least some of the newly generated cells develop finally into functional CP/PPn neurons.