The Use of Stem Cell Therapy to Reverse Opioid Tolerance
The Use of Stem Cell Therapy to Reverse Opioid Tolerance
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DOI：
10.1002/cpt.959
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发表时间：
2018-06
影响因子：
6.7
通讯作者：
Fei Li;Liping Liu;Kathleen Cheng;Zhongbo Chen;Jianguo Cheng
中科院分区：
文献类型：
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作者：
Fei Li;Liping Liu;Kathleen Cheng;Zhongbo Chen;Jianguo Cheng
阿片类药物耐受（OT）和阿片类药物引起的痛觉过敏（OIH）是医学上的主要挑战。在此，我们报道间充质干细胞 (MSC) 移植可预防和逆转大鼠和小鼠的 OT 和 OIH。不同评估方案的预防和治疗效果是持久且一致的。鞘内和静脉移植均有效且安全。因此，这种新兴的治疗策略有望影响临床实践并提高阿片类药物治疗的疗效和安全性。
Opioid tolerance (OT) and opioid‐induced hyperalgesia (OIH) are major challenges in medicine. Here we report that transplantation of mesenchymal stem cells (MSCs) prevented and reversed OT and OIH in rats and mice. The preventive and therapeutic effects were long‐lasting and consistent across different assessment schemes. Both intrathecal and intravenous transplantations were effective and safe. This emerging therapeutic strategy has thus shown promise to impact clinical practice and improve the efficacy and safety of opioid therapy.