Enlarged thalamic volumes and increased fractional anisotropy in the thalamic radiations in veterans with suicide behaviors.
Enlarged thalamic volumes and increased fractional anisotropy in the thalamic radiations in veterans with suicide behaviors.
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DOI：
10.3389/fpsyt.2013.00083
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发表时间：
2013
影响因子：
4.7
通讯作者：
Yurgelun-Todd D
中科院分区：
文献类型：
--
作者：
Lopez-Larson M;King JB;McGlade E;Bueler E;Stoeckel A;Epstein DJ;Yurgelun-Todd D
尸检研究表明丘脑、精神疾病和自杀之间存在联系。我们评估了一组有或没有自杀行为 (SB) 史的退伍军人的丘脑和前丘脑辐射 (ATR)，以确定丘脑异常是否与 SB 风险增加相关。 40 名患有轻度创伤性脑损伤 (TBI) 且无 SB (TBI-SB) 的退伍军人、19 名患有轻度 TBI 且有 SB 病史的退伍军人 (TB + SB) 和 15 名健康对照 (HC) 接受了磁共振成像扫描，包括结构和扩散张量成像扫描。使用哥伦比亚自杀评定量表评估 SB，并使用巴勒特冲动量表 (BIS) 测量冲动性。检查 (1) TBI + SB 与 HC 之间、(2) TBI + SB 与 HC 和 TBI-SB 组合之间以及 (3) TBI + SB 与 TBI-SB 之间丘脑体积和 ATR 分数各向异性 (FA) 的差异。与 HC、TBI-SB 和联合组相比，TBI + SB 组的左右丘脑体积显着增加。与 HC、HC 和 TBI-SB 组以及仅 TBI-SB 组相比，患有 TBI + SB 的退伍军人双侧 FA 增加。在 TBI + SB 组中发现双侧 ATR 和 BIS 呈显着正相关。我们对 TBI + SB 患者丘脑增大和 FA 增加的发现表明，该区域可能是自杀风险的生物标志物。我们的研究结果与之前的证据一致，表明自杀可能与行为去抑制和额叶-丘脑-边缘功能障碍有关，并表明可能增加自杀脆弱性的神经生物学机制。
Post-mortem studies have suggested a link between the thalamus, psychiatric disorders, and suicide. We evaluated the thalamus and anterior thalamic radiations (ATR) in a group of Veterans with and without a history of suicidal behavior (SB) to determine if thalamic abnormalities were associated with an increased risk of SB. Forty Veterans with mild traumatic brain injury (TBI) and no SB (TBI-SB), 19 Veterans with mild TBI and a history of SB (TB + SB), and 15 healthy controls (HC) underwent magnetic resonance imaging scanning including a structural and diffusion tensor imaging scan. SBs were evaluated utilizing the Columbia Suicide Rating Scale and impulsivity was measured using the Barratt Impulsiveness Scale (BIS). Differences in thalamic volumes and ATR fractional anisotropy (FA) were examined between (1) TBI + SB versus HC and (2) TBI + SB versus combined HC and TBI-SB and (3) between TBI + SB and TBI-SB. Left and right thalamic volumes were significantly increased in those with TBI + SB compared to the HC, TBI-SB, and the combined group. Veterans with TBI + SB had increased FA bilaterally compared to the HC, HC and TBI-SB group, and the TBI-SB only group. Significant positive associations were found for bilateral ATR and BIS in the TBI + SB group. Our findings of thalamic enlargement and increased FA in individuals with TBI + SB suggest that this region may be a biomarker for suicide risk. Our findings are consistent with previous evidence indicating that suicide may be associated with behavioral disinhibition and frontal-thalamic-limbic dysfunction and suggest a neurobiologic mechanism that may increase vulnerability to suicide.