Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients.
Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients.
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DOI：
10.1111/cas.13422
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发表时间：
2018-01
期刊：
影响因子：
5.7
通讯作者：
Maehara Y
中科院分区：
文献类型：
--
作者：
Katsura M;Shoji F;Okamoto T;Shimamatsu S;Hirai F;Toyokawa G;Morodomi Y;Tagawa T;Oda Y;Maehara Y
CXCR4/CXCR7/CXCL12趋化素轴在肿瘤细胞的迁移过程中发挥着重要的作用，它通过调控肿瘤局部的远处转移，包括区域淋巴结的转移。我们研究了这些趋化因子表达与淋巴结阳性非小细胞肺癌(NSCLC)患者预后的关系。收集140例累及肺门和(或)纵隔淋巴结(N1-2)的NSCLC原发灶(PS)和转移灶(MLN)标本。计算CXCR4、CXCR7和CXCL12的表达。用COX回归分析这些趋化因子是否为N1-2非小细胞肺癌的独立预后因素。CXCR4在PS中的高表达和CXCL12在MLN中的高表达与总生存率(OS)低相关(P分别为0.025和0.033)。PS中CXCR4的表达与MLN中CXCL12的表达显著相关(P=0.040)。PS中CXCR4和MLN中CXCL12的表达差异有统计学意义(P=0.0033)。CXCL12在MLN中的表达是一个独立的预后因素(HR 1.79，95%CI 1.08~3.04，P=0.023)。MLN中CXCL12主要由肿瘤细胞表达，而间质细胞表达CXCL12的比例为25%(P<；0.0001)。CXCR4/CXCL12可能在MLN的肿瘤进展中起作用，并与淋巴结阳性的NSCLC患者预后不良有关。
The CXCR4/CXCR7/CXCL12 chemokine axis plays important roles in the migration of tumor cells during cancer development by modulating site‐specific distant metastasis including to regional lymph nodes. We investigated the correlation of these chemokine expressions to prognosis in lymph‐node‐positive non‐small‐cell lung cancer (NSCLC) patients. A total of 140 surgically resected specimens of primary site (PS) and metastatic lymph nodes (MLN) of NSCLC involving hilar and/or mediastinal lymph nodes (N1‐2) were collected. CXCR4, CXCR7 and CXCL12 expressions were evaluated. Cox regression analysis was performed to determine whether these chemokines were independent prognostic factors in N1‐2 NSCLC. High expression of CXCR4 in PS and CXCL12 in MLN was associated with poor overall survival (OS) (P = .025 and .033, respectively). Significant correlations between CXCR4 expression in PS and CXCL12 expression in MLN were observed (P = .040). There was significant difference in OS between 2 groups according to expressions of CXCR4 in PS and CXCL12 in MLN (P = .0033). Expression of CXCL12 in MLN was identified as an independent prognostic factor (HR 1.79, 95% CI 1.08‐3.04, P = .023). CXCL12 in MLN was mainly expressed by tumor cells compared with stromal cells (56% vs 25%, respectively, P < .0001). CXCR4/CXCL12 may play roles in tumor progression in MLN and is associated with poor prognosis of lymph‐node‐positive NSCLC patients.
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影响因子：
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