Filtration markers and determination methods for the assessment of kidney function
Filtration markers and determination methods for the assessment of kidney function
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DOI：
10.1016/j.ejphar.2016.06.060
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发表时间：
2016-11-05
影响因子：
5
通讯作者：
Weinfurter, Stefanie
中科院分区：
文献类型：
--
作者：
Huang, Jiaguo;Gretz, Norbert;Weinfurter, Stefanie
肾功能的估计对于许多临床情况是至关重要的。内源性标志物如肌酐，以及几种外源性试剂，包括菊粉、（99）mTc-DTPA和碘酞酸盐，用于评价肾功能。目前，以有机荧光染料和荧光检测技术为基础的新一代过滤标记物和检测方法不断发展。本文综述了用于肾功能评估的滤过标志物和清除方法。新的滤过标志物和经皮测量肾功能的描述。还讨论了与每种标记物的重吸收或分泌以及方法的适用性有关的问题和问题。(C)© 2016 Elsevier B. V.版权所有。
Estimation of renal function is crucial for a number of clinical situations. Endogenous markers such as creatinine, as well as several exogenous agents including inulin, (99)mTc-DTPA and iothalamate are used for evaluation of kidney function. At present, new generation filtration markers and determination methods based on organic fluorescent dyes and fluorescent detection technique are developed. This review gives an overview of filtration markers and clearance methods for the assessment of kidney function. New filtration markers and transcutaneous measurement of renal function are described. Problems and issues relating to the reabsorption or secretion of each of markers and the applicability of methods are also discussed. (C) 2016 Elsevier B.V. All rights reserved.