Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer
Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer
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DOI：
10.1002/1097-0215(20001120)89:6
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发表时间：
2000-11-20
影响因子：
6.4
通讯作者：
Sidransky, D
中科院分区：
文献类型：
--
作者：
Chow, NH;Cairns, P;Sidransky, D
乳头状瘤和乳头状增生(PH)被认为是膀胱乳头状癌的前驱病变。我们在9条染色体上的17个微卫星标记上检测了15个PH病变和4个乳头状瘤的杂合性缺失(LOH)。15例PHS中有8例(53%)为克隆性，至少有1个微卫星标记存在杂合性缺失。相比之下，在测试的标记中，没有一个乳头状瘤显示出任何基因变化。在PH中，染色体9q丢失最多(4/15)，其次是9p和18q(n=2)，其次是8p、10q、11p和17p(n=1)。此外，2个增生性病变仅在9q出现杂合性缺失，证实了染色体9q上的等位基因Tass是膀胱癌进展的最早事件之一。在1例患者中，在PH和复发的移行细胞癌之间观察到相同的杂合性缺失模式。我们的分子数据表明，至少有一部分PHS代表膀胱癌前病变，这些病变随后发展为乳头状膀胱癌。此外，染色体臂9q可能含有一个肿瘤抑制基因(S)，该基因在人类膀胱癌发生的早期阶段就失活了。内部J·癌症(Pred.昂科尔，)89：5 14-518,2000。(C)Wiley-Liss公司
Papilloma and papillary hyperplasia (PH) have been proposed to be the putative precursor lesions of papillary transitional-cell carcinoma of the urinary bladder. We examined 15 PH lesions and 4 papillomas for loss of heterozygosity (LOH) at 17 microsatellite markers on 9 chromosomal arms. Eight of 15 (53%) PHs were clonal, demonstrating LOH of at least 1 microsatellite marker. In contrast, none of the papillomas showed any genetic changes among the markers tested. In PH, chromosomal arm 9q was the most frequently lost (4/15), followed by 9p and 18q (n = 2) and, less frequently, 8p, 10q, 11p and 17p(n = 1). Furthermore, 2 hyperplastic lesions demonstrated LOH at 9q only, confirming the notion that allelic tass on chromosomal arm 9q is among the earliest events in bladder-cancer progression. In I patient, identical LOH patterns were observed between PH and a recurrent transitional-cell carcinoma. Our molecular data demonstrate that at least a proportion of PHs represent pre cancerous lesions of the bladder that subsequently progress to papillary bladder cancer. Moreover, chromosomal arm 9q may harbor a tumor-suppressor gene(s) inactivated in the earliest stages of human bladder tumorigenesis. Int. J. Cancer (Pred. Oncol,) 89:5 14-518, 2000. (C) Wiley-Liss, Inc.