Medial and Lateral Networks in Anterior Prefrontal Cortex Support Metacognitive Ability for Memory and Perception
Medial and Lateral Networks in Anterior Prefrontal Cortex Support Metacognitive Ability for Memory and Perception
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DOI：
10.1523/jneurosci.0786-13.2013
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发表时间：
2013-10-16
影响因子：
5.3
通讯作者：
Margulies, Daniel S.
中科院分区：
文献类型：
--
作者：
Baird, Benjamin;Smallwood, Jonathan;Margulies, Daniel S.
趋同的证据表明，额极布罗德曼区10，更普遍的前额叶皮层（aPFC），支持人类的能力，监测和反映的认知和经验。然而，一个重要的未回答的问题是，aPFC是否是一个支持通用元生态能力的同质区域，或者在aPFC内部是否可能存在特定类型元生态过程的区域专业化。以往的研究表明，在aPFC的外侧和内侧细分可能支持元认知判断的时刻到时刻的知觉过程和评估的信息存储在较长的时间尺度，分别。在这里，我们直接比较了个体内变异的元认知能力的知觉决策和记忆判断，并使用静息态功能连接（rs-fcMRI），这种变异性的内侧和外侧区域的aPFC的连接。我们发现知觉和记忆判断的元认知能力存在行为分离。此外，功能连接分析揭示了不同的模式，连接与个体差异，在每个域。感知决策的元认知能力与aPFC外侧区域与右侧背侧前扣带皮层、双侧壳核、右侧尾状核和丘脑之间的连接性更强相关，而记忆提取的元认知能力预测内侧aPFC与右侧中央楔前叶和顶内沟/顶下小叶之间的连接性更强。总之，这些结果表明，一个人的能力，在感知和记忆领域的准确内省是有关的独特的神经网络的功能完整性锚定在内侧和外侧区域的aPFC。
Convergent evidence indicates that frontopolar Brodmann area 10, and more generally the anterior prefrontal cortex (aPFC), supports the human capacity to monitor and reflect on cognition and experience. An important unanswered question, however, is whether aPFC is a homogeneous region that supports a general-purpose metacognitive ability or whether there could be regional specialization within aPFC with respect to specific types of metacognitive processes. Previous studies suggest that the lateral and medial subdivisions within aPFC may support metacognitive judgments of moment-to-moment perceptual processes and assessments of information from memory stored over longer time scales, respectively. Here we directly compared intraindividual variability in metacognitive capacity for perceptual decisions and memorial judgments and used resting-state functional connectivity(rs-fcMRI) to relate this variability to the connectivity of the medial and lateral regions of aPFC. We found a behavioral dissociation in metacognitive ability for perceptual and memorial judgments. Furthermore, functional connectivity analysis revealed distinct patterns of connectivity that correlated with individual differences in each domain. Metacognitive ability for perceptual decisions was associated with greater connectivity between lateral regions of aPFC and right dorsal anterior cingulate cortex, bilateral putamen, right caudate, and thalamus, whereas metacognitive ability for memory retrieval predicted greater connectivity between medial aPFC and the right central precuneus and intraparietal sulcus/inferior parietal lobule. Together, these results suggest that an individual's capacity for accurate introspection in the domains of perception and memory is related to the functional integrity of unique neural networks anchored in the medial and lateral regions of the aPFC.