Effects of Mecamylamine on Alcohol Consumption and Preference in Male C57BL/6J Mice
Effects of Mecamylamine on Alcohol Consumption and Preference in Male C57BL/6J Mice
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DOI：
10.1159/000219488
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发表时间：
2009-01-01
期刊：
影响因子：
3.1
通讯作者：
Barron, Susan
中科院分区：
文献类型：
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作者：
Farook, Justin M.;Lewis, Ben;Barron, Susan
酒精和尼古丁（以烟草的形式）是两种常用的消遣性毒品，研究表明烟草使用和酒精消费之间存在高度相关性。在本研究中，我们使用C57BL/6J小鼠，通过2瓶选择测试饮用程序，研究了甲胺（一种烟碱拮抗剂）在24小时自由获取的情况下减少酒精消耗和酒精偏好的能力。雄性C57BL/6J小鼠单独饲养并适应10%酒精。在酒精适应的最后一天之后，小鼠（n=5/组）立即皮下注射甲胺（0.5,1和2 mg/kg）或生理盐水，包括间歇性（每隔一天注射3次）或每日（所有5天注射）暴露。每天记录液体消耗（酒精和水）。结果表明，在间歇和每日药物暴露的两个阶段，甲美胺显著降低了酒精消耗和酒精偏好，而总液体消耗不变。这些结果进一步支持了甲胺在减少酒精消耗和偏好方面是有效的，并且基于尼古丁受体的药物可以进一步探索作为酒精中毒的潜在治疗方法。版权所有(C) 2009 S. Karger AG，巴塞尔
Alcohol and nicotine (in the form of tobacco) are 2 commonly used recreational drugs and studies show a high correlation between tobacco use and alcohol consumption. In the present study, using C57BL/6J mice, we investigated the ability of mecamylamine (a nicotinic antagonist) to reduce alcohol consumption and alcohol preference with free 24-hour access using a 2-bottle choice test drinking procedure. Male C57BL/6J mice were individually housed and acclimatized to 10% alcohol. Immediately following the last day of alcohol acclimatization, the mice (n=5/group) received subcutaneous injections of mecamylamine (0.5, 1 and 2 mg/kg) or saline consisting of either intermittent (3 injections given every other day) or daily (injections on all 5 days) exposures. Fluid consumption (alcohol and water) was recorded daily. The results showed that mecamylamine significantly reduced alcohol consumption and alcohol preference in both phases of intermittent and daily drug exposures, while the total fluid consumption was unchanged. These results provide further support that mecamylamine is effective in reducing alcohol consumption and preference, and nicotinic-receptor-based drugs could further be explored as potential treatments for alcoholism. Copyright (C) 2009 S. Karger AG, Basel