Swertifrancheside, an HIV-reverse transcriptase inhibitor and the first flavone-xanthone dimer, from Swertia franchetiana.
Swertifrancheside, an HIV-reverse transcriptase inhibitor and the first flavone-xanthone dimer, from Swertia franchetiana.
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DOI：
10.1021/np50104a003
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发表时间：
1994-02
影响因子：
5.1
通讯作者：
J. Wang;C. Hou;Y. L. Liu;L. Lin;R. Gil;G. Cordell
中科院分区：
文献类型：
--
作者：
J. Wang;C. Hou;Y. L. Liu;L. Lin;R. Gil;G. Cordell
第一个黄酮-呫吨酮C-葡萄糖苷獐牙菜甙是从獐牙菜中分离出来的，并通过光谱分析阐明了其结构为1,5,8-三羟基-3-甲氧基-7-(5',7',3'',4''-) 四羟基-6'-C-β-D-吡喃葡萄糖基-4'-氧基-8'-黄酮）-呫吨酮。该化合物是一种中等强度的 HIV 逆转录酶抑制剂。
The first flavone-xanthone C-glucoside, swertifrancheside, was isolated from Swertia franchetiana, and its structure was elucidated on the basis of spectroscopic analysis as 1,5,8-trihydroxy-3-methoxy-7-(5',7',3'',4''- tetrahydroxy-6'-C-beta-D-glucopyranosyl-4'-oxy-8'-flavyl)-xanthone . This compound was a moderately potent inhibitor of HIV reverse transcriptase.