Inflammation and colorectal cancer: colitis-associated neoplasia.
Inflammation and colorectal cancer: colitis-associated neoplasia.
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炎症和大肠癌：结肠炎相关的肿瘤。
DOI：
10.1007/s00281-012-0352-6
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发表时间：
2013-03
影响因子：
9
通讯作者：
Grivennikov, Sergei I.
中科院分区：
文献类型：
--
作者：
Grivennikov, Sergei I.
炎症和癌症之间的联系是一个快速发展的领域。流行病学数据表明，炎症沿着宿主免疫系统的不同分支在许多不同癌症的发生和发展中起着非常重要的作用。炎症性肠病（IBD）是结肠癌（即结肠炎相关癌（CAC））发生的重要危险因素。炎症促进癌症发展的分子机制仍在探索中，CAC和其他形式的结直肠癌之间可能存在差异。最近的工作已经阐明了不同的免疫细胞，细胞因子和其他免疫介质在结肠肿瘤发生的几乎所有步骤中的作用，包括肿瘤的起始和促进以及进展和转移。结肠肿瘤与无数肠道微生物的密切接近，以及微生物群在IBD中的工具作用，将微生物引入能够引发炎症并可能促进肿瘤发生的新参与者。本文就CAC肿瘤发生的各种机制以及未来预防和治疗的新方法进行了讨论。
Connection between inflammation and cancer is a rapidly developing field. Epidemiological data suggests that inflammation along with distinct arms of host immune system plays a very important role in development and progression of many different cancers. Inflammatory bowel diseases (IBD) is an important risk factor for the development of colon cancer, namely colitis-associated cancer (CAC). The molecular mechanisms by which inflammation promotes cancer development are still being uncovered and may differ between CAC and other forms of colorectal cancer. Recent work has shed light on the role of distinct immune cells, cytokines and other immune mediators in virtually all of the steps of colonic tumorigenesis, including tumor initiation and promotion as well as progression and metastasis. The close proximity of colonic tumors to the myriad of intestinal microbes, as well as instrumental role of microbiota in IBD, introduces microbes as new players capable of triggering inflammation and possibly promoting tumorigenesis. Various mechanisms of CAC tumorigenesis as well as new possible hints for the future approaches for prevention and therapy are discussed in this review.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1084/jem.20100050
发表时间：
2010-05-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allen IC;TeKippe EM;Woodford RM;Uronis JM;Holl EK;Rogers AB;Herfarth HH;Jobin C;Ting JP
通讯作者：
Ting JP
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
17.1
作者：
Blumberg R;Powrie F
通讯作者：
Powrie F