Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms.
Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms.
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DOI：
10.1364/ol.37.001193
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发表时间：
2012-04-01
期刊：
影响因子：
3.6
通讯作者：
Pogue BW
中科院分区：
文献类型：
--
作者：
Glaser AK;Zhang R;Davis SC;Gladstone DJ;Pogue BW
来自线性加速器的辐射诱导组织中的切伦科夫发射，其最近已被证明产生生化光谱特征，其可被解释为估计组织血红蛋白和氧饱和度或来自报告分子的分子荧光。切伦科夫光学光级在10−6-10−9 W/cm 2的范围内，这限制了信号在常规放射治疗监测中的实际应用。然而，由于辐射是脉冲的，信号的门控采集允许在存在环境照明的情况下进行检测，如这里所示。这一观察结果有可能显着增加切伦科夫发射光谱在放射治疗期间的价值，以监测组织分子事件。
Radiation from a linear accelerator induces Cerenkov emission in tissue, which has recently been shown to produce biochemical spectral signatures which can be interpreted to estimate tissue hemoglobin and oxygen saturation or molecular fluorescence from reporters. The Cerenkov optical light levels are in the range of 10−6–10−9 W/cm2, which limits the practical utility of the signal in routine radiation therapy monitoring. However due to the fact that the radiation is pulsed, gated-acquisition of the signal allows detection in the presence of ambient lighting, as is demonstrated here. This observation has the potential to significantly increase the value of Cerenkov emission spectroscopy during radiation therapy to monitor tissue molecular events.