Diversity, classification and function of the plant protein kinase superfamily
Diversity, classification and function of the plant protein kinase superfamily
复制标题
DOI：
10.1098/rstb.2012.0003
复制
发表时间：
2012-09-19
影响因子：
6.3
通讯作者：
Shiu, Shin-Han
中科院分区：
文献类型：
--
作者：
Lehti-Shiu, Melissa D.;Shiu, Shin-Han
真核蛋白激酶属于一个拥有数百至数千个拷贝的大型超家族，并且是基本上所有细胞功能的组成部分。本研究的目标是对 25 种植物的蛋白激酶进行分类，并结合其分子功能评估其进化历史。蛋白激酶超家族在开花植物谱系中得到了扩展，部分原因是最近的复制。因此，开花植物蛋白激酶库（或称为激酶组）通常明显大于其他真核生物，其成员数量从 600 到 2500 个不等。激酶组大小的这种巨大变化主要是由于一些家族的扩张和收缩，特别是受体样激酶/Pelle家族。许多蛋白激酶存在于高度保守、低拷贝数的家族中，并且通常在代谢和细胞分裂中发挥广泛保守的调节作用，尽管植物同源物的功能通常与其后生动物对应物不同。扩展的植物激酶家族的成员通常在植物特异性过程中发挥作用，其中一些可能有助于适应性进化。尽管如此，非适应性解释，例如激酶重复亚功能化和假生成时间不足，也可能导致植物中出现大量看似有功能的蛋白激酶。
Eukaryotic protein kinases belong to a large superfamily with hundreds to thousands of copies and are components of essentially all cellular functions. The goals of this study are to classify protein kinases from 25 plant species and to assess their evolutionary history in conjunction with consideration of their molecular functions. The protein kinase superfamily has expanded in the flowering plant lineage, in part through recent duplications. As a result, the flowering plant protein kinase repertoire, or kinome, is in general significantly larger than other eukaryotes, ranging in size from 600 to 2500 members. This large variation in kinome size is mainly due to the expansion and contraction of a few families, particularly the receptor-like kinase/Pelle family. A number of protein kinases reside in highly conserved, low copy number families and often play broadly conserved regulatory roles in metabolism and cell division, although functions of plant homologues have often diverged from their metazoan counterparts. Members of expanded plant kinase families often have roles in plant-specific processes and some may have contributed to adaptive evolution. Nonetheless, non-adaptive explanations, such as kinase duplicate subfunctionalization and insufficient time for pseudogenization, may also contribute to the large number of seemingly functional protein kinases in plants.