Peripheral blood memory B cells are resistant to apoptosis in chronic hepatitis C patients
Peripheral blood memory B cells are resistant to apoptosis in chronic hepatitis C patients
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DOI：
10.1016/j.virusres.2010.09.017
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发表时间：
2011-01-01
期刊：
影响因子：
5
通讯作者：
Yamaguchi, Kazunari
中科院分区：
文献类型：
--
作者：
Mizuochi, Toshiaki;Ito, Masahiko;Yamaguchi, Kazunari
我们最近的研究表明，慢性丙型肝炎（CHC）患者外周血B细胞存在丙型肝炎病毒（HCV）感染。研究还表明，CHC患者外周血中CD 27（+）B细胞（即记忆表型）的频率显著降低。根据这些发现，我们假设当感染HCV时，CD 27（+）B细胞易发生凋亡。因此，本研究分析了CHC患者CD 27（+）B细胞对凋亡的易感性。与我们的假设相反，发现CD 27（+）B细胞比对应的亚群，即CD 27（-）B细胞更耐凋亡。关于记忆B细胞作为慢性丙型肝炎患者持续感染的HCV储存库的可能作用，讨论了这一发现的基本原理。(c)2010爱思唯尔有限公司版权所有。
Our recent study indicated that peripheral B cells in chronic hepatitis C (CHC) patients were infected with hepatitis C virus (HCV). It was also demonstrated that the frequency of CD27(+) B cells, i.e. memory phenotype, was significantly reduced in the peripheral blood of CHC patients. An assumption was made by these findings that the CD27(+) B cells are susceptible to apoptosis when infected with HCV. Therefore, in this study, the susceptibility of CD27(+) B cells to apoptosis in CHC patients was analyzed. Contrary to our assumption, it was found that CD27(+) B cells are more resistant to apoptosis than the counterpart subset, i.e. CD27(-) B cells. The rationale for this finding is discussed with regard to the possible role for memory B cells as an HCV reservoir for persistent infection in CHC patients. (c) 2010 Elsevier B.V. All rights reserved.