Analgesic Effect of Moxibustion with Different Temperature on Inflammatory and Neuropathic Pain Mice: A Comparative Study
Analgesic Effect of Moxibustion with Different Temperature on Inflammatory and Neuropathic Pain Mice: A Comparative Study
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不同温度艾灸对炎症性神经病理性疼痛小鼠镇痛作用的比较研究
DOI：
10.1155/2017/4373182
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发表时间：
2017-01-01
影响因子：
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通讯作者：
Yu, Shuguang
中科院分区：
文献类型：
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作者：
Zhou, Wei;Lei, Ruxue;Yu, Shuguang
本研究旨在探讨艾灸过程中温度的变化是否会产生镇痛效应的分区。采用不同温度（37 ℃、42 ℃、47 ℃、52 ℃）艾灸慢性炎症性或神经病理性疼痛小鼠的ST 36穴30 min。采用慢性炎性痛的热痛敏实验和神经病理性痛的机械痛敏实验评价镇痛效果。结果表明，不同温度的艾灸干预对完全弗氏佐剂（CFA）所致慢性炎性痛和备用神经损伤（SNI）所致神经病理性痛的镇痛作用不同。在慢性炎性疼痛中，不同的艾灸温度产生不同强度的镇痛作用，越高越好。在慢性神经源性疼痛中，47 ℃、52 ℃灸的镇痛作用较37 ℃、42 ℃灸强。而艾灸温度47 ℃与52 ℃、37 ℃与42 ℃之间无显著性差异。提示艾灸治疗慢性炎症性疼痛或神经源性疼痛时应考虑温度的影响。
The aim of this study was to determine whether variation of temperature during moxibustion would generate division of analgesic effect. The moxibustion with different temperatures (37 degrees C, 42 degrees C, 47 degrees C, and 52 degrees C) was applied to ST36 acupoint for 30 minutes in chronic inflammatory or neuropathic pain mice. The analgesic effect was evaluated by thermal hyperalgesia test in chronic inflammatory pain and by mechanical allodynia in neuropathic pain, respectively. The results indicated that interventions of moxibustion with different temperature caused different analgesic effect on either chronic inflammatory induced by injection of complete Freund's adjuvant (CFA) or neuropathic pain induced by spared nerve injury (SNI). In chronic inflammatory pain, different moxibustion temperature generated different intensity of analgesic effect: the higher the better. In chronic neuropathic pain, stronger analgesic effect was found in moxibustion with temperature 47 degrees C or 52 degrees C other than 37 degrees C and 42 degrees C. However, there is no significant difference displayed between moxibustion temperatures 47 degrees C and 52 degrees C or 37 degrees C and 42 degrees C. It implies that the temperature should be taken into account for moxibustion treatment to chronic inflammatory or neuropathic pain.