TRANSFUSION, RECURRENCE, AND INFECTION IN HEAD AND NECK-CANCER SURGERY
TRANSFUSION, RECURRENCE, AND INFECTION IN HEAD AND NECK-CANCER SURGERY
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DOI：
10.1177/019459989210600129
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发表时间：
1992-01-01
影响因子：
3.4
通讯作者：
HILSINGER, RL
中科院分区：
文献类型：
--
作者：
VONDOERSTEN, P;CRUZ, RM;HILSINGER, RL
输血的有害影响已经被记录在案--特别是外科肿瘤学家，他们认为输血诱导的免疫抑制会增加复发和感染并发症的发生率。我们在头颈部的外科肿瘤学中研究了这种关系。在符合严格的纳入标准后，104名患者进入了这项研究，研究了临床、手术、病理、实验室和治疗性质的31个变量。多因素分析显示，输血对复发或感染并发症没有显著影响。单因素分析显示，感染并发症与输血有关(p=0.029)。年龄(p=0.024)、术后血红蛋白水平(p=0.049)和区域淋巴结转移(p=0.0015)对复发有显著影响。在之前的三项耳鼻喉科研究中，输血已被证明影响复发；然而，有两项研究仅使用了单变量分析。由于这是第一个检查输血与感染并发症关系的耳鼻喉科研究之一，所以使用多变量分析进行前瞻性研究是有必要的。同时，输血的决定应继续取决于患者的临床状况。
The detrimental effects of transfusion have been documented-particularly by surgical oncologists, who believe transfusion-induced immunosuppression increases the incidence of recurrence and infectious complications. We examined this relation in surgical oncology of the head and neck. After meeting strict inclusion criteria, 104 patients were entered into the study, in which 31 variables of a clinical, surgical, pathologic, laboratory, and treatment nature were studied. Multivariate analysis showed transfusion did not significantly affect recurrence or infectious complications. However, by univariate analysis, infectious complications were related to transfusion (p = 0.029). The variables age (p = 0.024), postoperative hemoglobin level (p = 0.049), and spread to regional lymph node (p = 0.0015) were found to significantly affect the incidence of recurrence. In the three previous otolaryngologic studies, transfusions had been shown to affect recurrence; however, two studies used univariate analysis only. Since this is one of the first otolaryngologic studies to examine the relation of transfusion with infectious complications, prospective studies using multivariate analysis are warranted. Meanwhile, the decision to transfuse should continue to depend on the clinical status of the patient.