Intrahepatic cholangiocarcinoma arising in cirrhotic liver frequently expressed p63-positive basal/stem-cell phenotype
Intrahepatic cholangiocarcinoma arising in cirrhotic liver frequently expressed p63-positive basal/stem-cell phenotype
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DOI：
10.1016/j.prp.2005.10.011
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发表时间：
2006-01-01
影响因子：
2.8
通讯作者：
Takano, Y
中科院分区：
文献类型：
--
作者：
Nomoto, K;Tsuneyama, K;Takano, Y
一般来说，肝内胆管细胞癌(ICC)与肝硬变无关。然而，已有少数病例报道ICC合并严重的肝纤维化。一些研究人员提出，肝细胞胆管细胞癌(HC-CC)可能起源于肝脏前体细胞，是一种可能发生于肝硬变的中间混合表型。在肝脏中，肝细胞和胆管细胞形成上皮细胞，但间质和间充质细胞可能由肝干细胞产生。基于这些方面，不仅是HC-CC，而且还有其他细胞表型的组合，将涵盖所有具有干细胞特征的癌症。在这项旨在确定ICC表型特征的研究中，我们用免疫组织化学方法检测了基础/干细胞标记物p63在有无肝硬变的ICC中的表达，以及细胞角蛋白(CK)34βE12和c-kit的表达。在肝硬变的ICC中，p63基因的异常表达最为常见。这一结果提示ICC癌细胞起源于具有潜在多向分化潜能的肝脏前体细胞。(C)2005年爱思唯尔股份有限公司。版权所有。
In general, intrahepatic cholangiocarcinoma (ICC) is not related to liver cirrhosis. However, a few cases have been reported in which ICC was accompanied by severe liver fibrosis. Some researchers have proposed that hepatocellular and cholangiocellular (HC-CC) carcinoma, an intermediate mixed phenotype possibly arising in cirrhotic liver, might originate from hepatic precursor cells. In the liver, hepatocytes and cholangiocytes form the epithelial element, but stromal and mesenchymal elements may be produced by hepatic stem cells. Based on these aspects, not only HC-CC, but also other combinations of cellular phenotypes, would cover all the cancers with stem cell features. In this study, which aimed at determining the characteristics of the ICC phenotype, we used immunohistochemistry to examine the expression of basal/stem-cell markers, i.e., p63 in ICC with and without liver cirrhosis, as well as the expressions of cytokeratin (CK) 34 beta E12, specific for the basal-cell marker, and c-kit, specific for the stem-cell marker. Aberrant p63 was frequently expressed in ICC arising in cirrhotic liver. This result suggests that ICC cancer cells originate from hepatic precursor cells with a hidden multi-differentiation potential. (c) 2005 Elsevier GmbH. All rights reserved.