Advances and Challenges of Liposome Assisted Drug Delivery.
Advances and Challenges of Liposome Assisted Drug Delivery.
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DOI：
10.3389/fphar.2015.00286
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发表时间：
2015
影响因子：
5.6
通讯作者：
Hua S
中科院分区：
文献类型：
--
作者：
Sercombe L;Veerati T;Moheimani F;Wu SY;Sood AK;Hua S
脂质体辅助药物输送的应用已经在许多生物医学领域产生了重大影响。它们已被证明有利于稳定治疗性化合物，克服细胞和组织摄取的障碍，并改善化合物在体内靶部位的生物分布。这使得封装的化合物能够有效地递送到目标部位，同时最大限度地减少全身毒性。脂质体由于其灵活的物理化学和生物物理特性而成为一种有吸引力的递送系统，这使得易于操作以解决不同的递送问题。尽管在过去的50年里进行了大量的研究，并且在临床前研究中取得了大量的积极结果，但脂质体辅助给药平台的临床转化正在逐步取得进展。在这篇综述中，我们将讨论脂质体辅助药物递送的进展，仍然存在的生物学挑战，以及目前脂质体在生物医学应用中的临床和实验应用。脂质体技术的转化障碍也将被提出。
The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. This enables effective delivery of encapsulated compounds to target sites while minimizing systemic toxicity. Liposomes present as an attractive delivery system due to their flexible physicochemical and biophysical properties, which allow easy manipulation to address different delivery considerations. Despite considerable research in the last 50 years and the plethora of positive results in preclinical studies, the clinical translation of liposome assisted drug delivery platforms has progressed incrementally. In this review, we will discuss the advances in liposome assisted drug delivery, biological challenges that still remain, and current clinical and experimental use of liposomes for biomedical applications. The translational obstacles of liposomal technology will also be presented.