A marker for Stevens-Johnson syndrome ...: ethnicity matters
A marker for Stevens-Johnson syndrome ...: ethnicity matters
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DOI：
10.1038/sj.tpj.6500356
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发表时间：
2006-07-01
影响因子：
2.8
通讯作者：
Roujeau, J. -C.
中科院分区：
文献类型：
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作者：
Lonjou, C.;Thomas, L.;Roujeau, J. -C.
史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是罕见但严重的皮肤药物不良反应，可由一定数量的特定药物引起，其中包括抗癫痫药卡马西平。最近在中国汉族人群中发现卡马西平诱导的 SJS 与 HLA-B*1502 存在非常强的相关性。在此，我们报告了一项欧洲研究 (RegiSCAR) 的初步结果，该研究对 12 例卡马西平诱发的 SJS/10 例（9 例法国和 3 例德国）进行了研究。其中只有四个具有 HLA-B*1502 等位基因。值得注意的是，据我们所知，这四名患者有亚洲血统，而其他患者则没有。这表明，尽管 HLA 区域可能包含 SJS 的重要基因，但 HLA-B*1502 等位基因并不是该疾病的通用标记，而且种族也很重要。
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe cutaneous adverse drug reactions, which can be caused by a certain number of specific drugs among which is carbamazepine, an antiepileptic agent. A very strong association of carbamazepine-induced SJS with HLA-B*1502 has recently been described in the Han Chinese population. Here in, we report preliminary results from a European study (RegiSCAR) of 12 carbamazepine-induced SJS/TEN cases (nine French and three German). Among these only four had a HLA-B*1502 allele. Remarkably, these four patients had an Asian ancestry, whereas the others did not as far as we have ascertained. This shows that although the HLA region may contain important genes for SJS, the HLA-B*1502 allele is not a universal marker for this disease and that ethnicity matters.