Estrogen and neurodegeneration
Estrogen and neurodegeneration
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DOI：
10.1023/a:1023246921127
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发表时间：
2003-07-01
影响因子：
4.4
通讯作者：
Gandy, S
中科院分区：
文献类型：
--
作者：
Gandy, S
虽然雌激素最为人所知的是其对初级和次级性器官的成熟和分化的影响，但越来越多的证据表明，其影响超出了这一系统，其在中枢神经系统中的活性可能会引发或影响我们对神经退行性衰退的易感性。雌激素被认为在几个水平上起着一般神经保护剂的作用，很可能由于绝经而导致的雌激素缺乏会使衰老或患病的大脑受到几种损害。此外，雌激素缺乏可能引发或增强由氧化应激引起的退行性变化，并降低大脑维持突触连接和胆碱能完整性的能力，导致在老年人和受疾病折磨的个体中观察到的认知能力下降。
Although estrogen is best known for its effects on the maturation and differentiation of the primary and secondary sex organs, increasing evidence suggests that its influence extends beyond this system, and its activity in the CNS may initiate, or influence our susceptibility to neurodegenerative decline. Estrogen has been proposed to act as a general neuroprotectant at several levels and it is probable that deprivation of estrogen as a result of menopause exposes the aging, or diseased brain to several insults. In addition, estrogen deprivation is likely to initiate, or enhance degenerative changes caused by oxidative stress, and to reduce the brain's ability to maintain synaptic connectivity and cholinergic integrity leading to the cognitive decline seen in aged, and disease-afflicted individuals.