Bone involvement in Hodgkin's disease.
Bone involvement in Hodgkin's disease.
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DOI：
10.1111/j.1440-1673.1993.tb00011.x
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发表时间：
1993-02-01
期刊：
影响因子：
--
通讯作者：
Benjamin, C S
中科院分区：
文献类型：
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作者：
Borg, M F;Chowdhury, A D;Benjamin, C S
何杰金氏病的骨受累是不常见的，在最初诊断时很少遇到。从1980年至1988年在奥克兰医院治疗的147例霍奇金病患者中确定了7例骨受累性病例。只有一名患者在初次就诊时发现有骨病变。2例多发病变，5例单发病变。受累部位包括脊柱、骨盆、股骨、肱骨、肋骨、胸骨、肩胛骨和颅底。6例为结节性硬化组织学，1例为混合性细胞性疾病。7例晚期患者均行全身化疗，5例患者需行受累骨部位局部放疗。使用6兆电子伏特直线加速器或钴机进行个体化的辐射剂量计划，范围从30 Gy到40 Gy。在本研究分析时，4例患者完全缓解，2例患者完成化疗，反应良好，仅有1例患者死于弥散性疾病。目前的回顾显示了令人鼓舞的治疗反应和良好的长期控制。我们认为，联合治疗是有效的治疗何杰金氏病骨性受累。
Bone involvement in Hodgkin's disease is uncommon and seldom encountered at initial diagnosis. Seven cases with osseous involvement were identified from a series of 147 patients with Hodgkin's disease treated at Auckland Hospital from 1980 to 1988. Only one patient was found to have bone lesions at the time of initial presentation. Two patients had multiple lesions and 5 had a solitary lesion. Sites of involvement included the spine, pelvis, femur, humerus, ribs, sternum, scapula and base of skull. Six patients had nodular sclerosing histology and one had mixed cellularity disease. All 7 patients were treated with systemic chemotherapy for their advanced disease, and 5 patients needed local radiotherapy to sites of bone involvement. The radiation dosage schedules were individualized, ranging from 30 Gy to 40 Gy, using either a 6 MeV linear accelerator or cobalt machine. At the time of analysis of this study, 4 patients were in complete remission, 2 patients completed chemotherapy with good response and only 1 patient died of disseminated disease. The current review has demonstrated an encouraging response to treatment and good long term control. We believe that combined-modality therapy is effective in the treatment of osseous involvement in Hodgkin's disease.