Hyperacute stroke: Simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time
Hyperacute stroke: Simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time
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DOI：
10.1148/radiology.210.2.r99fe06519
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发表时间：
1999-02-01
期刊：
影响因子：
19.7
通讯作者：
Koroshetz, WJ
中科院分区：
文献类型：
--
作者：
Sorensen, AG;Copen, WA;Koroshetz, WJ
目得：探讨提供的额外信息地图的相对脑血流量在功能磁共振（MR）成像的人类超急性脑缺血性stroke.MATERIALS和METHODS：扩散加权和血流动力学MR成像进行了23例不到12小时后，症状发作。计算相对脑血流量和示踪剂平均组织通过时间图，以及表观弥散和相对脑血容量图。急性病变体积的地图进行了比较，后续的成像findings.Results：在15的23名受试者（65%），血流图显示血流动力学异常，血容量地图上不可见。初始血流量和弥散结果之间的不匹配更常预测梗死的增长（15例梗死增长的受试者中有12例），而初始血容量和弥散结果之间的不匹配（15例中有8例）。然而，血容量和弥散图上的病变体积与最终梗死体积的相关性（r > 0.90）优于血流和示踪剂平均通过时间图上的病变体积（r类似于0.6），这可能是阈值效应的结果。在8例患者中，血容量周围的扩散异常升高，提示代偿性血流动力学response.CONCLUSION：MR成像卡尔描绘领域的改变血流，血容量，水流动性在超急性人类中风。组织结果的预测模型可以通过包括相对脑血流量和血容量两者的计算而受益。
PURPOSE: To investigate additional information provided by maps of relative cerebral blood flow in functional magnetic resonance (MR) imaging of human hyperacute cerebral ischemic stroke.MATERIALS AND METHODS: Diffusion-weighted and hemodynamic MR imaging were performed in 23 patients less than 12 hours after the onset of symptoms. Maps of relative cerebral blood flow and tracer mean tissue transit time were computed, as were maps of apparent diffusion and relative cerebral blood volume. Acute lesion volumes on the maps were compared with follow-up imaging findings.RESULTS: In 15 of 23 subjects (65%), blood flow maps revealed hemodynamic abnormalities not visible on blood volume maps. A mismatch between initial blood flow and diffusion findings predicted growth of infarct more often (12 of 15 subjects with infarcts that grew) than did a mismatch between initial blood volume and diffusion findings (eight of 15). However, lesion volumes on blood volume and diffusion maps correlated better with eventual infarct volumes (r > 0.90) than did those on blood flow and tracer mean transit time maps (r similar to 0.6), likely as a result of threshold effects. In eight patients, blood volume was elevated around the diffusion abnormality, suggesting a compensatory hemodynamic response.CONCLUSION: MR imaging carl delineate areas of altered blood flow, blood volume, and water mobility in hyperacute human stroke. Predictive models of tissue outcome may benefit by including computation of both relative cerebral blood flow and blood volume.