Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients
Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients
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DOI：
10.1128/jcm.40.2.704-706.2002
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发表时间：
2002-02-01
影响因子：
9.4
通讯作者：
Andersen, P
中科院分区：
文献类型：
--
作者：
Doherty, TM;Demissie, A;Andersen, P
潜伏结核分枝杆菌感染的诊断被认为对于结核病控制至关重要，但由于缺乏特异性试剂而受到阻碍。我们报告说，结核病患者的健康家庭接触者对结核病复合物特异性抗原 ESAT-6 的强烈识别与随后 2 年随访期间活动性结核病的发展相关。
Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for tuberculosis control but is hampered by the lack of specific reagents. We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period.