Computed tomographic-lymphography as a complementary technique for lymph node staging in dogs with malignant tumors of various sites
Computed tomographic-lymphography as a complementary technique for lymph node staging in dogs with malignant tumors of various sites
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DOI：
10.1111/vru.12569
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发表时间：
2018-03-01
影响因子：
1.7
通讯作者：
Bley, Carla Rohrer
中科院分区：
文献类型：
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作者：
Rossi, Federica;Korner, Maximilian;Bley, Carla Rohrer
常规检查局部区域淋巴结，以确定肿瘤的空间范围。由于某些肿瘤类型的引流模式可能与预期的解剖分布不同，因此采样真正代表引流区域的淋巴是至关重要的。这项双中心前瞻性先导性研究的目的是描述计算机断层扫描(CT)-淋巴造影术在犬肿瘤分期中用于一次引流淋巴标测的技术。对45只犬在特定部位的巨大或微观肿瘤进行了评估。根据体重的不同，在肿瘤周围的四个象限内注射0.8-2ml的对比剂(碘海醇)，分别在注射后1、3、6、9和12分钟获得CT图像。在平扫研究中，284个感兴趣区(Hounsfield单位)的衰减和增强模式被评估，中位数HUS为31.1(四分位数范围=18.4)，在静脉注射后研究中，275个淋巴结的HU为104.3(HU=31.2)(配对的Wilcoxon检验，P
Locoregional lymph nodes are routinely examined in order to define the spatial extent of neoplastic disease. As draining patterns of certain tumor types can be divergent from expected anatomical distribution, it is critical to sample the lymph nodes truly representing the draining area. The aim of this bicenter prospective pilot study was to describe the technique of computed tomographic (CT)-lymphography for primary draining lymph node mapping in tumor staging in dogs. Forty-five dogs with macro- or microscopic tumors in specified localizations were evaluated. Depending on body weight, 0.8-2ml contrast agent (iohexol) was injected into four quadrants around the tumor, and CT-images were obtained at 1, 3, 6, 9, and 12minutes post-injection. Attenuation of chosen regions of interest (Hounsfield units (HU)) and patterns of enhancement were assessed for 284 lymph nodes in the precontrast study with median HUs of 31.1 (Interquartile range (IQR)=18.4) and for 275 in the intravenous postcontrast study with 104.3 HU (IQR=31.2) (paired Wilcoxon test, P