Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system
Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system
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DOI：
10.1016/s0028-3908(02)00069-2
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发表时间：
2002-07-01
影响因子：
4.7
通讯作者：
Sillaber, I
中科院分区：
文献类型：
--
作者：
Keck, ME;Welt, T;Sillaber, I
重复经颅磁刺激（rTMS）被认为是一个潜在的有用的治疗抑郁症。为了优化rTMS的治疗用途，有必要了解所涉及的神经生物学机制，特别是诱导的神经化学变化的性质。使用脑内微透析在麻醉和清醒的成年雄性Wistar大鼠，我们监测急性rTMS（20 Hz）对海马内，脑内和纹状体内多巴胺及其代谢产物（高香草酸，3，4-二羟基苯乙酸）的释放模式的影响。根据大鼠脑中rTMS诱导的电流密度分布的精确的基于MRI的计算机辅助重建的结果来调整刺激参数，确保额叶脑区域的刺激。在背侧海马，货架的nucleus和背侧纹状体的细胞外多巴胺浓度显着升高，响应rTMS。两者合计，这些数据提供了第一个在体内的证据表明，急性rTMS的额叶脑区具有调节作用的中脑边缘和纹状体多巴胺能系统。多巴胺能神经传递的增加可能有助于rTMS治疗情感障碍和帕金森病的有益作用。(C)2002爱思唯尔科技有限公司。保留所有权利。
Repetitive transcranial magnetic stimulation (rTMS) is suggested to be a potentially useful treatment in major depression. In order to optimize rTMS for therapeutic use, it is necessary to understand the neurobiological mechanisms involved, particularly the nature of the neurochemical changes induced. Using intracerebral microdialysis in urethane-anesthetized and conscious adult male Wistar rats, we monitored the effects of acute rTMS (20 Hz) on the intrahippocampal, intraaccumbal and intrastriatal release patterns of dopamine and its metabolites (homovanillic acid, 3,4-dihydroxyphenylacetic acid). The stimulation parameters were adjusted according to the results of accurate MRI-based computer-assisted reconstructions of the Current density distributions induced by rTMS in the rat brain, ensuring stimulation of frontal brain regions. In the dorsal hippocampus, the shelf of the nucleus accumbens and the dorsal striatum the extracellular concentration of dopamine was significantly elevated in response to rTMS. Taken together, these data provide the first in vivo evidence that acute rTMS of frontal brain regions has a modulatory effect on both the mesolimbic and the mesostriatal dopaminergic systems. This increase in dopaminergic neurotransmission may contribute to the beneficial effects of rTMS in the treatment of affective disorders and Parkinson's disease. (C) 2002 Elsevier Science Ltd. All rights reserved.