FIBROBLAST GROWTH-FACTORS
FIBROBLAST GROWTH-FACTORS
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DOI：
10.1093/oxfordjournals.bmb.a072333
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发表时间：
1989-04-01
影响因子：
6.7
通讯作者：
WALICKE, PA
中科院分区：
文献类型：
--
作者：
BAIRD, A;WALICKE, PA
40 多年前，人们就提出了成纤维细胞生长因子 (FGF) 的存在，以解释组织提取物刺激成纤维细胞增殖的能力。20 世纪 70 年代，人们逐渐清楚，含有 FGF 活性的制剂实际上具有多效性，可影响多种间质细胞、内分泌细胞和神经细胞的生长和功能。它们的血管生成作用促进了心脏病学和神经学的研究，因为它们在刺激侧支血管形成和缺血恢复方面发挥了作用。它们与肿瘤血管生成因子活性成分的同一性刺激了肿瘤学研究，它们增强伤口愈合、神经再生和软骨修复的能力影响了神经病学、骨科医学和病理学的研究。 FGF 的潜在治疗价值才刚刚开始被认识到，并且将依赖于确定其在正常细胞稳态调节和疾病病理生理学中的功能的共同努力。
The existence of fibroblast growth factors (FGFs) was proposed over 40 years ago to account for the ability of tissue extracts to stimulate fibroblast proliferation In the 1970s it became clear that preparations containing FGF activity were in fact pleiotropic, affecting the growth and function of a wide variety of mesenchymal, endocrine and neural cells. Their angiogenic effects have promoted research in cardiology and neurology because of their proposed role in stimulating collateral vascularisation and recovery from ischemia. Their identity with a component of tumour angiogenesis factor activity has stimulated research in oncology and their capacity to enhance wound healing, nerve regeneration and cartilage repair has affected research in neurology, orthopaedic medicine and pathology. The potential therapeutic value of FGFs is just beginning to be realized and will be dependent on a concerted effort to establish their function in the regulation of normal cell homeostais and the pathophysiology of disease.