Microscopically positive resection margin after hepatoblastoma resection: what is the impact on prognosis? A Childhood Liver Tumours Strategy Group (SIOPEL) report
Microscopically positive resection margin after hepatoblastoma resection: what is the impact on prognosis? A Childhood Liver Tumours Strategy Group (SIOPEL) report
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DOI：
10.1016/j.ejca.2018.10.013
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发表时间：
2019-01-01
影响因子：
8.4
通讯作者：
Brugieres, Laurence
中科院分区：
文献类型：
--
作者：
Aronson, Daniel C.;Weeda, Viola B.;Brugieres, Laurence
背景：评价显微阳性切除切缘(MicroPRM)对接受化疗的肝母细胞瘤患者预后的影响。方法：分析SIOPEL 2和3试验中431例接受化疗的儿童的局部复发率和生存率，并与371例完全切除(CR)和371例完全切除(CR)的患者进行比较。在312名患者中，肿瘤是标准风险和高风险(借口IV和/或肝外疾病和/或甲胎蛋白[AFP]
Background: To evaluate the impact of a microscopically positive resection margin (microPRM) on the outcome of hepatoblastoma patients pretreated with chemotherapy.Methods: Local recurrence and survival rates of 431 children treated in the SIOPEL 2 and 3 trials were analysed comparing 58 patients with microPRM with 371 who had a complete resection (CR) and who were then stratified by risk category. The tumour was standard-risk in 312 patients and high-risk (PRETEXT IV and/or extrahepatic disease and/or alpha-fetoprotein [AFP]