Assessment of abdominal adipose tissue and organ fat content by magnetic resonance imaging.
Assessment of abdominal adipose tissue and organ fat content by magnetic resonance imaging.
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DOI：
10.1111/j.1467-789x.2010.00824.x
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Goran MI
中科院分区：
文献类型：
--
作者：
Hu HH;Nayak KS;Goran MI
随着肥胖症患病率的持续上升，迫切需要快速准确的工具来评估腹部身体和器官脂肪的数量和分布，以帮助研究人员研究针对肥胖症及其合并症的治疗和预防措施。磁共振成像（MRI）是最有前途的方式来解决这种需求。它是非侵入性的，不利用电离辐射，提供无与伦比的3D可视化，可重复，适用于所有年龄段的受试者队列。本文旨在为读者提供MRI和脂肪定量相关图像分析方法的当前和最新技术的概述。传统的方法，如T1加权成像和磁共振波谱以及更现代的化学位移成像技术的基本原理进行了讨论和比较。强调了连续3D采集相对于2D多切片方法的优势。解释了从腹部MRI数据集提取脂肪组织贮库体积和器官脂肪含量百分比的典型后处理程序。此外，还提供了每种MRI方法在成像参数、空间分辨率、受试者运动、扫描时间和适当的脂肪定量终点方面的优点和缺点。在实施这些方法的实际考虑。
As the prevalence of obesity continues to rise, rapid and accurate tools for assessing abdominal body and organ fat quantity and distribution are critically needed to assist researchers investigating therapeutic and preventive measures against obesity and its comorbidities. Magnetic resonance imaging (MRI) is the most promising modality to address such need. It is non-invasive, utilizes no ionizing radiation, provides unmatched 3D visualization, is repeatable, and is applicable to subject cohorts of all ages. This article is aimed to provide the reader with an overview of current and state-of-the-art techniques in MRI and associated image analysis methods for fat quantification. The principles underlying traditional approaches such as T1-weighted imaging and magnetic resonance spectroscopy as well as more modern chemical-shift imaging techniques are discussed and compared. The benefits of contiguous 3D acquisitions over 2D multi-slice approaches are highlighted. Typical post-processing procedures for extracting adipose tissue depot volumes and percent organ fat content from abdominal MRI data sets are explained. Furthermore, the advantages and disadvantages of each MRI approach with respect to imaging parameters, spatial resolution, subject motion, scan time, and appropriate fat quantitative endpoints are also provided. Practical considerations in implementing these methods are also presented.