Line Active Hybrid Lipids Determine Domain Size in Phase Separation of Saturated and Unsaturated Lipids
Line Active Hybrid Lipids Determine Domain Size in Phase Separation of Saturated and Unsaturated Lipids
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DOI：
10.1016/j.bpj.2009.11.027
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发表时间：
2010-03-17
影响因子：
3.4
通讯作者：
Safran, Samuel A.
中科院分区：
文献类型：
--
作者：
Brewster, Robert;Safran, Samuel A.
杂合脂质（例如，具有一个完全饱和链和一个部分不饱和链的POPC）表明这些脂质优先堆积在相分离的饱和和不饱和结构域之间的弯曲界面处。我们预测，域的大小通常范围从几十到几百纳米，这取决于分子的相互作用和参数，如分子体积和面积每头基，在体相流体。胆固醇的作用是考虑到一个有效的头基面积的变化和域的大小预计将增加胆固醇浓度。
A simple model of the line activity of a hybrid lipid (e.g., POPC) with one fully saturated chain and one partially unsaturated chain demonstrates that these lipids preferentially pack at curved interfaces between phase-separated saturated and unsaturated domains. We predict that the domain sizes typically range from tens to hundreds of nm, depending on molecular interactions and parameters such as molecular volume and area per headgroup, in the bulk fluid phase. The role of cholesterol is taken into account by an effective change in the headgroup areas and the domain sizes are predicted to increase with cholesterol concentration.