EFFECT OF THE 8-AMINOQUINOLINE PRIMAQUINE ON CULTURE-DERIVED GAMETOCYTES OF THE MALARIA PARASITE PLASMODIUM-FALCIPARUM
EFFECT OF THE 8-AMINOQUINOLINE PRIMAQUINE ON CULTURE-DERIVED GAMETOCYTES OF THE MALARIA PARASITE PLASMODIUM-FALCIPARUM
复制标题
DOI：
10.1007/bf00928413
复制
发表时间：
1991-01-01
影响因子：
2
通讯作者：
LANNERS, HN
中科院分区：
文献类型：
--
作者：
LANNERS, HN
将恶性疟原虫洪都拉斯I/CDC克隆株HB-3的配子细胞暴露于不同浓度的二磷酸伯氨喹。可以证明，这种药物通过破坏细胞的内部结构并使这些细胞器膨胀来对细胞的线粒体起特异性作用。
Gametocytes from the Honduras I/CDC clone HB-3 of Plasmodium falciparum were exposed to different concentrations of primaquine diphosphate. It could be shown that the drug acts specifically on the mitochondria of the cells by destroying their internal structure and causing these organelles to swell.