FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder
FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder
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DOI：
10.1002/jbio.201200126
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发表时间：
2013-01-01
影响因子：
2.8
通讯作者：
Gardner, Peter
中科院分区：
文献类型：
--
作者：
Hughes, Caryn;Iqbal-Wahid, Junaid;Gardner, Peter
膀胱尿路上皮癌是一组异质性的肿瘤，虽然一些组织学的亚变体是罕见的，在文献中报道稀少。常规尿路上皮癌的亚变体的诊断可能具有挑战性，因为它们可能模仿其他恶性肿瘤或良性肿瘤的形态，因此它们的区别很重要。这是第一次，光谱病理的一些这些子变种已被记录的红外显微光谱，并试图描绘他们的生物化学。重要的是，不仅要从常见的组织特征（如基质或血液）中识别和分离癌症相关的上皮组织光谱，而且要检测肿瘤亚变体的特征。如图所示，它们的光谱信号可以由于分化而显著改变。示例情况下进行了讨论，并与组织学评价进行比较。
Urothelial carcinomas of the bladder are a heterogeneous group of tumours, although some histological sub-variants are rare and sparsely reported in the literature. Diagnosis of sub-variants from conventional urothelial carcinoma can be challenging, as they may mimic the morphology of other malignancies or benign tumours and therefore their distinction is important. For the first time, the spectral pathology of some of these sub-variants has been documented by infrared microspectroscopy and an attempt made to profile their biochemistry. It is important not only to identify and separate the cancer-associated epithelial tissue spectra from common tissue features such as stroma or blood, but also to detect the signatures of tumour sub-variants. As shown, their spectroscopic signals can change dramatically as a consequence of differentiation. Example cases are discussed and compared with histological evaluations.