The Role of Mitochondria in Drosophila Aging
The Role of Mitochondria in Drosophila Aging
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DOI：
10.1016/j.exger.2010.08.010
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发表时间：
2011-05-01
影响因子：
3.9
通讯作者：
Walker, David W.
中科院分区：
文献类型：
--
作者：
Cho, Jaehyoung;Hur, Jae H.;Walker, David W.
了解不同细胞和组织中线粒体功能的改变如何影响衰老过程仍然是生物学家面临的最大挑战之一。在这里，我们讨论了最近在这方面的研究热潮，果蝇作为一个模型系统。讨论的主题包括线粒体功能的年龄相关变化，线粒体氧化应激和寿命，通过中度敲低线粒体电子传递链（ETC）功能重要基因介导的寿命延长，以及饮食限制和ETC活性之间的关系。最后，我们回顾了最近的方法来补充内源性飞ETC与单亚基线粒体呼吸酶从酵母。(C)2010年爱思唯尔公司All rights reserved.
Understanding how alterations in mitochondrial function in different cells and tissues impacts the aging process remains one of the greatest challenges facing biogerontologists. Here, we discuss the recent upsurge in research in this area using the fruit fly Drosophila melanogaster as a model system. Topics that are discussed include age-related changes in mitochondrial function, mitochondrial oxidative stress and lifespan, life extension mediated by moderate knock-down of genes important for mitochondrial electron transport chain (ETC) function, and the relationship between dietary restriction and ETC activity. Finally, we review recent approaches to supplement the endogenous fly ETC with a single-subunit mitochondrial respiratory enzyme from yeast. (C) 2010 Elsevier Inc. All rights reserved.