Associations of Green Tea Consumption and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Pathology in Cognitively Intact Older Adults: The CABLE Study
Associations of Green Tea Consumption and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Pathology in Cognitively Intact Older Adults: The CABLE Study
复制标题
认知完整的老年人中绿茶摄入量与阿尔茨海默病病理学脑脊液生物标志物的关联：CABLE 研究。
DOI：
10.3233/jad-200410
复制
发表时间：
2020-01-01
影响因子：
4
通讯作者：
Yu, Jin-Tai
中科院分区：
文献类型：
--
作者：
Ma, Ya-Hui;Wu, Jia-Huan;Yu, Jin-Tai
背景资料：绿色茶在改善认知障碍和阿尔茨海默病（AD），特别是认知功能障碍的进展方面已被广泛认可。目的：本研究旨在确定饮用绿色茶与AD病理学脑脊液（CSF）生物标志物之间的关系，并确定特定人群背景是否对这些关系表现出差异。方法：多变量线性模型分析了722名认知完整的参与者的CSF生物标志物和绿色茶消费频率的可用数据。中国阿尔茨海默病生物标志物和生活方式（CABLE）数据库，我们还检测了茶叶消费与APOE 84状态和性别的交互作用，使用双向协方差分析。频繁饮用绿色茶与CSF总tau蛋白（t-tau）水平降低相关（p = 0.041），但与CSF淀粉样蛋白-β（42）（A β（42））和CSF磷酸化tau的水平无关。在65岁或更年轻的个体中观察到绿色茶消费与CSF t-tau（p = 0.007）和CSF t-tau/A β（42）（p = 0.039）的更明显的关联。此外，经常饮用绿色茶的男性的CSF t-tau/A β水平显著较低（42），并且CSF t-tau水平有适度降低的趋势。绿色茶消费与APOE β 4和gender.Conclusion没有交互作用：总的来说，我们的研究结果巩固了绿色茶对减轻AD风险的有利影响。绿色茶的成分可以改善异常的tau代谢，并且是干预和药物治疗中有希望的靶点。
Background: Green tea has been widely recognized in ameliorating cognitive impairment and Alzheimer's disease (AD), especially the progression of cognitive dysfunction. But the underlying mechanism is still unclear.Objective: This study was designed to determine the role of green tea consumption in the association with cerebrospinal fluid (CSF) biomarkers of AD pathology and to ascertain whether specific population backgrounds showed the differences toward these relationships.Methods: Multivariate linear models analyzed the available data on CSF biomarkers and frequency of green tea consumption of 722 cognitively intact participants from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) database, and we additionally detected the interaction effects of tea consumption with APOE 84 status and gender using a two-way analysis of covariance.Results: Frequent green tea consumption was associated with a decreased level of CSF total-tau protein (t-tau) (p = 0.041) but not with the levels of CSF amyloid-beta(42) (A beta(42)) and CSF phosphorylated tau. The more pronounced associations of green tea consumption with CSF t-tau (p = 0.007) and CSF t-tau/A beta(42) (p = 0.039) were observed in individuals aged 65 years or younger. Additionally, males with frequent green tea consumption had a significantly low level of CSF t-tau/A beta(42) and a modest trend toward decreased CSF t-tau. There were no interaction effects of green tea consumption with APOE epsilon 4 and gender.Conclusion: Collectively, our findings consolidated the favorable effects of green tea on the mitigation of AD risk. The constituents of green tea may improve abnormal tau metabolism and are promising targets in interventions and drug therapies.