PRODUCTION OF SPONTANEOUS DIABETIC RATS BY REPETITION OF SELECTIVE BREEDING
PRODUCTION OF SPONTANEOUS DIABETIC RATS BY REPETITION OF SELECTIVE BREEDING
复制标题
DOI：
10.1620/tjem.119.85
复制
发表时间：
1976-01-01
影响因子：
2.2
通讯作者：
MASAKI, N
中科院分区：
文献类型：
--
作者：
GOTO, Y;KAKIZAKI, M;MASAKI, N
这项研究是在一个工作假设下进行的，即重复选择繁殖葡萄糖耐量轻微受损的正常大鼠将产生自发性糖尿病大鼠。18只大鼠通过口服葡萄糖耐量试验从实验动物农场获得的211只正常Wistar大鼠中挑选出来。通过饲养，共获得162只F1代大鼠。用这种方法选育获得F2代204只、F3代174只、F4代215只。平均糖耐量曲线随着世代数的增加而变得更加糖尿病。糖耐量试验中尿糖试验阳性病例的百分比随着世代数的增加而增加。结果表明，通过重复选育，正常大鼠有可能产生自发性糖尿病。
This study was conducted under a working hypothesis that the repeating of selective breeding of normal rats with a slight impairment of glucose tolerance would produce spontaneous diabetes in rats. Rats (18) were selected by an oral glucose tolerance test from 211 normal Wistar rats obtained from an experimental animal farm. By breeding, 162 F1 rats were obtained. By the selective breeding in this way, 204 F2, 174 F3 and 215 F4 rats were obtained. The mean glucose tolerance curve became more diabetic with the increasing number of generations. The percentage of cases of a positive test for urine sugar during the glucose tolerance test increased with the number of generation. The results indicate the possibility of production of spontaneous diabetes from normal rats by the repetition of the selective breeding.