Draft Genome Sequences of Yersinia pestis Isolates from Natural Foci of Endemic Plague in China
Draft Genome Sequences of Yersinia pestis Isolates from Natural Foci of Endemic Plague in China
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DOI：
10.1128/jb.01227-09
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发表时间：
2009-12-15
影响因子：
3.2
通讯作者：
Ravel, Jacques
中科院分区：
文献类型：
--
作者：
Eppinger, Mark;Guo, Zhaobiao;Ravel, Jacques
为了深入了解鼠疫病原体的进化起源、出现和致病性，我们对从中国地方性鼠疫疫源地人兽共患鼠疫宿主中分离的4株鼠疫耶尔森氏菌进行了基因组测序。这些资源能够深入研究鼠疫耶尔森氏菌的序列变异，并对假定的全球鼠疫大流行的起源地和出现地点非常密切的相关基因组进行详细的全基因组比较。
To gain insights into the evolutionary origin, emergence, and pathogenicity of the etiologic agent of plague, we have sequenced the genomes of four Yersinia pestis strains isolated from the zoonotic rodent reservoir in foci of endemic plague in China. These resources enable in-depth studies of Y. pestis sequence variations and detailed whole-genome comparisons of very closely related genomes from the supposed site of the origin and the emergence of global pandemics of plague.