Physiological Effect and Therapeutic Application of Alpha Lipoic Acid
Physiological Effect and Therapeutic Application of Alpha Lipoic Acid
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DOI：
10.2174/0929867321666140706141806
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发表时间：
2014-01-01
影响因子：
4.1
通讯作者：
Lee, In-Kyu
中科院分区：
文献类型：
--
作者：
Park, Sungmi;Karunakaran, Udayakumar;Lee, In-Kyu
1951年，α -硫辛酸被确定为丙酮酸和α -酮戊二酸氧化脱羧的催化剂，并得到了化学家、生物学家、临床医生对它在能量代谢和保护免受活性氧诱导的线粒体功能障碍中的作用感兴趣。因此，补充硫辛酸的许多生物学效应可归因于α -硫辛酸和二氢α -硫辛酸的有效抗氧化特性。细胞内的还原环境有助于防止氧化损伤，α -硫辛酸的还原氧化状态取决于细胞成分处于氧化状态的程度。虽然健康的年轻人可以合成足够的α -硫辛酸来清除活性氧，增强内源性抗氧化剂，如谷胱甘肽和维生素C和E，但α -硫辛酸的水平随着年龄的增长而显著下降，这可能导致内皮功能障碍。此外，许多研究报道α -硫辛酸可以调节与抗氧化和抗炎途径相关的基因转录。在这篇综述中，我们将讨论最近的临床研究，研究α -硫辛酸对内皮功能障碍的有益作用，并提出可能的机制。
Reactive oxygen species and reactive nitrogen species promote endothelial dysfunction in old ageand contribute to the development of cardiovascular diseases such as atherosclerosis, diabetes, and hypertension alpha-lipoic acid was identified as a catalytic agent for oxidative decarboxylation of pyruvate and alpha-ketoglutarate in 1951, and it has been studied intensively by chemists, biologists, and clinicians who have been interested in its role in energetic metabolism and protection from reactive oxygen species-induced mitochondrial dysfunction. Consequently, many biological effects of lipoic acid supplementation can be attributed to the potent antioxidant properties of alpha-lipoic acid and dihydro alpha-lipoic acid. The reducing environments inside the cell help to protect from oxidative damage and the reduction-oxidation status of alpha-lipoic acid is dependent upon the degree to which the cellular components are found in the oxidized state. Although healthy young humans can synthesize enough alpha-lipoic acid to scavenge reactive oxygen species and enhance endogenous antioxidants like glutathione and vitamins C and E, the level of alpha-lipoic acid significantly declines with age and this may lead to endothelial dysfunction. Furthermore, many studies have reported alpha-lipoic acid can regulate the transcription of genes associated with anti-oxidant and anti-inflammatory pathways. In this review, we will discuss recent clinical studies that have investigated the beneficial effects of alpha-lipoic acid on endothelial dysfunction and propose possible mechanisms involved.