Gd-EOB-DTPA enhanced MRI for hepatocellular carcinoma: quantitative evaluation of tumor enhancement in hepatobiliary phase.
Gd-EOB-DTPA enhanced MRI for hepatocellular carcinoma: quantitative evaluation of tumor enhancement in hepatobiliary phase.
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DOI：
10.2463/mrms.4.1
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发表时间：
2005-01-01
期刊：
影响因子：
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通讯作者：
Shimazaki, Yoko
中科院分区：
文献类型：
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作者：
Saito, Kazuhiro;Kotake, Fumio;Shimazaki, Yoko
目的：探讨Gd-EOB-DTPA增强磁共振成像(MRI)定量评价肝细胞癌(HCC)和肝胆系发育不良结节的价值。材料和方法：12例患者27个病灶(22个肝癌和5个发育不良结节)。分别在注射Gd-EOB-DTPA前、注射后10、20、40min获得化学位移选择性脂肪抑制的T1加权序列。结果：注射Gd-EOB-DTPA后10、20、40min肝细胞的增强率分别为44.0+/-36.5、44.7+/-46.8、47.7+/-52.8(%)。增强率分别为36.2+/-34.3、44.3+/-37.3和40.1+/-46.8(%)。注射Gd-EOB-DTPA后10、20、40min，平扫肝细胞C/N比值分别为0.2+/-6.6、-9.2+/-12.6、-9.9+/-14.8、-12.7+/-15.7。发育不良结节的C/N比值分别为1.4+/-8.0、-13.7+/-11.1、-13.3+/-7.6和-13.1+/-10.4。肝细胞癌和发育不良结节的强化比和C/N值无显著差异。仅2例肝细胞癌C/N比值为阳性，病理证实为高分化癌和中分化癌。结论：肝细胞癌和部分发育不良结节在Gd-EOB-DTPA增强MRI上表现为肝胆期低信号。无论肿瘤分化程度如何，均未观察到特异性增强。
OBJECTIVE: The purpose of this study was to evaluate the utility of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the quantitative evaluation of hepatocellular carcinoma (HCC) and dysplastic nodules in the hepatobiliary phase.MATERIAL AND METHODS: The subjects comprised 12 patients with 27 lesions (22 HCCs and 5 dysplastic nodules). Chemical-shift-selective fat-suppressed T1-weighted sequences were obtained before and 10, 20, and 40 min after the injection of Gd-EOB-DTPA. Quantitative analyses were performed with the enhancement ratio of the lesion and the contrast-to-noise (C/N) ratio.RESULTS: The enhancement ratios of the HCCs were 44.0+/-36.5, 44.7+/-46.8, and 47.7+/-52.8 (%) at 10, 20, and 40 min, respectively, after the injection of Gd-EOB-DTPA. The enhancement ratios of the dysplastic nodules were 36.2+/-34.3, 44.3+/-37.3, and 40.1+/-46.8 (%). The C/N ratios of the HCCs were 0.2+/-6.6 for the precontrast image, and -9.2+/-12.6, -9.9+/-14.8, and -12.7+/-15.7 at 10, 20, and 40 min, respectively, after the injection of Gd-EOB-DTPA. The C/N ratios of the dysplastic nodules were 1.4+/-8.0, -13.7+/-11.1, -13.3+/-7.6, and -13.1+/-10.4. No significant differences were found between the HCCs and the dysplastic nodules in the enhancement ratio and the C/N ratio. Only two HCCs showed a positive C/N ratio value, and these HCCs were pathologically confirmed to be a well differentiated and a moderately differentiated carcinoma, respectively.CONCLUSION: HCCs and some of the dysplastic nodules showed hypointensity in the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI. No specific enhancement was observed, regardless of tumor differentiation.