Biodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriers
Biodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriers
复制标题
DOI：
10.1002/app.1295
复制
发表时间：
2001-06-13
影响因子：
3
通讯作者：
He, BL
中科院分区：
文献类型：
--
作者：
Liu, L;Li, CX;He, BL
以阿霉素(ADR)为模型药物，评价聚乳酸/聚乙二醇/聚乳酸胶束作为药物载体在肠外给药系统中的应用前景。用动态光散射法和透射电子显微镜对聚乳酸/聚乙二醇/聚乳酸三嵌段共聚物胶束进行了表征。结果表明，随着聚乳酸链长的增加，胶束尺寸增大。阿霉素胶束的平均粒径为143.2 nm。直方图分析表明，ADR胶束具有较窄的单峰尺寸分布。胶束中ADR的载药量和包封率与共聚物中的聚乳酸和聚乙二醇链的长度有关。它们随着聚乳酸链长的增加而增加，但聚乙二醇链的长度相同，随着聚乙二醇链的增加而减小；聚乳酸嵌段的长度基本相同。ADR初始量也影响药物含量和包封率(即初始量越大，药物含量越多，包封率越高)。药物释放实验表明，阿霉素胶束具有缓释特性。(C)2001年John Wiley&Sons，Inc.
Adriamycin (ADR) was selected as a model drug to evaluate the potential applications of polylactide/poly(ethylene glycol)/polylactide (PLA/PEG/PLA) micelles as drug carriers in parenteral delivery systems. The PLA/PEG/PLA triblock copolymer micelles were characterized by dynamic light scattering and transmission electron microscopy. It was found that the micelle size increased with the increasing of the PLA chain length. The average size of ADR-loaded micelles was 143.2 nm. The histogram analysis showed that the ADR-loaded micelles possessed a narrow unimodal size distribution. The ADR loading contents of the micelles and ADR entrapment efficiency were dependent on the PLA chain length and PEG chain length in the copolymer. They increased with the increase of the PLA chain length, but the PEG chain length was identical and decreased with the increase of the PEG chain length; the length of the PLA block was similar. The initial amount of ADR also influenced the drug contents and entrapment efficiency (i.e., the more the initial amount added, the more the drug contents and the higher encapsulation efficiency). The drug release experiments indicated that the ADR-loaded micelles possessed sustained release characteristics. (C) 2001 John Wiley & Sons, Inc.