Cytokine mRNA expression patterns in the disease course of female adolescents with anorexia nervosa
Cytokine mRNA expression patterns in the disease course of female adolescents with anorexia nervosa
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DOI：
10.1016/s0306-4530(02)00131-2
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发表时间：
2004-01-01
影响因子：
3.7
通讯作者：
Schmidt, MH
中科院分区：
文献类型：
--
作者：
Kahl, KG;Kruse, N;Schmidt, MH
神经性厌食症（AN）是一种严重的进食障碍，其特征是体重极度减轻，神经内分泌和免疫系统异常。细胞因子已被讨论参与恶病质的病理机制。因此，我们的研究旨在研究肿瘤坏死因子-α（TNF-α），干扰素-γ（IFN-γ），白细胞介素-6（IL-6）和白细胞介素-10（IL-10）的mRNA表达模式在全血中的11名女性AN患者和10名年龄和性别匹配的正常体重对照组使用敏感的定量聚合酶。链反应（PCR）方法。我们发现，与对照组相比，厌食症患者入院时（平均BMI 14.8 ± 1.3）TNF-α和IL-6 mRNA表达显著增加。在随访过程中，TNF-α mRNA的表达在以前的厌食症患者（平均BMI 18.7 +/-0.5）中仍然显著较高，而IL-6 mRNA的表达降低。我们解释我们的研究结果表明，TNF-α可能有助于神经性厌食症的代谢异常，即使在目标BMI达到。(C)2003爱思唯尔有限公司。保留所有权利。
Anorexia nervosa (AN) is a serious eating disorder characterized by extreme weight loss and abnormalities of the neuroendocrine and immune systems. Cytokines have been discussed to be involved in the pathomechanisms underlying cachexia. Therefore our study aimed at examining the mRNA expression pattern of tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-6 (IL-6) and interleukin-10 (IL-10) in whole blood of 11 female AN patients and 10 age and sex matched normal weight control subjects using a sensitive quantitative polymerase. chain reaction (PCR) method. We found a significant increase in TNF-alpha and IL-6 mRNA expression in anorectic patients at admission (mean BMI 14.8 +/- 1.3) when compared to controls. During follow-up, the expression of TNF-a mRNA remained significantly higher in formerly anorectic patients (mean BMI 18.7 +/- 0.5) while IL-6 mRNA expression decreased. We interpret our results as suggesting that TNF-alpha may contribute to metabolic abnormalities in anorexia nervosa even after goal BMI is achieved. (C) 2003 Elsevier Ltd. All rights reserved.