Diacylglyceride kinases, sphingosine kinases and NAD kinases: distant relatives of 6-phosphofructokinases
Diacylglyceride kinases, sphingosine kinases and NAD kinases: distant relatives of 6-phosphofructokinases
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DOI：
10.1016/s0968-0004(02)02093-5
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发表时间：
2002-06-01
影响因子：
13.8
通讯作者：
Gilles, AM
中科院分区：
文献类型：
--
作者：
Labesse, G;Douguet, D;Gilles, AM
甘油二酯、鞘氨醇、NAD和6-磷酸果糖激酶被认为是相关的，尽管它们的序列发生了很大的进化。由于发现了一个共同的特征，人们认为它们具有相似的磷酸供体结合部位和相似的磷酸化机制。底物和变构结合位置的差异更大，它们的划分还有待实验确定。
Diacylglyceride kinases, sphingosine kinases, NAD kinases and 6-phosphofructokinases are thought to be related despite large evolution of their sequences. Discovery of a common signature has led to the suggestion that they possess a similar phosphate-donor-binding site and a similar phosphorylation mechanism. The substrate- and allosteric-binding sites are much more divergent and their delineation remains to be determined experimentally.