Clinical utility of microarchitecture measurements of trabecular bone.
Clinical utility of microarchitecture measurements of trabecular bone.
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DOI：
10.1007/s11914-006-0004-7
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发表时间：
2006-06-01
影响因子：
4.3
通讯作者：
Majumdar, Sharmila
中科院分区：
文献类型：
--
作者：
Carballido-Gamio, Julio;Majumdar, Sharmila
骨质疏松症是一种代谢性疾病，表现为骨密度和结构的变化，并伴有骨折易感性增加。最近的研究证明了骨小梁微结构在评估新兴治疗方法的疗效以及评估骨折风险方面的潜在贡献。本文的主要目标是强调骨微结构测量的临床实施。因此，本文概述了描述骨小梁微结构的主要成像方式，并对常见的计算结构骨参数进行了相应的描述。用于表征复杂的三维骨小梁网络的成像方式包括显微 CT、定量 CT 和磁共振成像。还讨论了射线照相图案的二维分析。还针对各种成像方式提供了纵向研究中基于骨小梁微结构区分不同人群的能力的结果。
Osteoporosis is a metabolic disorder that manifests changes in bone density and structure accompanied by an increased susceptibility to fractures. Recent studies have demonstrated the potential contributions of trabecular bone microarchitecture in the assessment of the therapeutic efficacy of emerging treatments, and also in the assessment of fracture risk. The main goal of this paper is to emphasize the clinical implementation of bone microarchitecture measurements. Thus, this paper provides an overview of the main imaging modalities for depicting trabecular bone microarchitecture and a corresponding description of common computed structural bone parameters. The imaging modalities presented to characterize the complex three-dimensional trabecular bone network include micro-CT, quantitative CT, and magnetic resonance imaging. Two-dimensional analyses of radiographic patterns are also discussed. Results demonstrating the ability to distinguish between different populations based on trabecular bone microarchitecture in longitudinal studies are also presented for the various imaging modalities.