PennPET Explorer: Design and Preliminary Performance of a Whole-Body Imager
PennPET Explorer: Design and Preliminary Performance of a Whole-Body Imager
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DOI：
10.2967/jnumed.119.229997
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发表时间：
2020-01-01
影响因子：
9.3
通讯作者：
Daube-Witherspoon, Margaret E.
中科院分区：
文献类型：
--
作者：
Karp, Joel S.;Viswanath, Varsha;Daube-Witherspoon, Margaret E.
我们报告的PennPET探索者全身成像仪的发展。方法：PennPET Explorer是一种多环系统，设计有长轴向视野。该成像仪是可扩展的，包括多个22.9厘米长的环段，每个环段有18个基于商用数字硅光电倍增管的检测器模块。一个原型3段成像器已经完成，并测试了一个积极的64厘米轴向视野。结果：仪器的设计进行了描述，并提出了其物理性能测量。这些包括55 kcps/MBq的灵敏度，4.0 mm的空间分辨率，12%的能量分辨率，256 ps的时间分辨率，以及超过30 kBq/mL的1，000 kcps以上的噪声等效计数率。在评价病变躯干体模以表征定量准确性后，对健康志愿者进行人体研究。结论：物理性能测量验证了系统设计，并导致高质量的人体研究。
We report on the development of the PennPET Explorer whole-body imager. Methods: The PennPET Explorer is a multiring system designed with a long axial field of view. The imager is scalable and comprises multiple 22.9-cm-long ring segments, each with 18 detector modules based on a commercial digital silicon photomultiplier. A prototype 3-segment imager has been completed and tested with an active 64-cm axial field of view. Results: The instrument design is described, and its physical performance measurements are presented. These include sensitivity of 55 kcps/MBq, spatial resolution of 4.0 mm, energy resolution of 12%, timing resolution of 256 ps, and a noise-equivalent count rate above 1,000 kcps beyond 30 kBq/mL. After an evaluation of lesion torso phantoms to characterize quantitative accuracy, human studies were performed on healthy volunteers. Conclusion: The physical performance measurements validated the system design and led to high-quality human studies.