Medical, reproductive and psychosocial experiences of women diagnosed with von Willebrand's disease receiving care in haemophilia treatment centres: a case-control study
Medical, reproductive and psychosocial experiences of women diagnosed with von Willebrand's disease receiving care in haemophilia treatment centres: a case-control study
复制标题
DOI：
10.1046/j.1365-2516.2003.00756.x
复制
发表时间：
2003-05-01
期刊：
影响因子：
3.9
通讯作者：
Evatt, B
中科院分区：
文献类型：
--
作者：
Kirtava, A;Drews, C;Evatt, B
目的：评估血管性血友病（VWD）妇女的医疗、妇科和生殖经历，并评估VWD对心理健康和生活活动的影响。方法：对在美国血友病治疗中心（HTCs）登记的102名VWD妇女和88名对照组进行了关于医疗、妇科和生殖史、生活活动和抑郁症状的访谈。使用流行病学研究中心抑郁量表（CES-D）测量抑郁症状。结果：与6%的对照组相比，74%的VWD病例报告了大量出血症状。与对照组相比，患有VWD的妇女在月经过多、产后大出血、其他妇科疾病、关节炎和偏头痛方面的患病率更高。与对照组相比，更多的VWD病例报告说，月经对整体生活活动有负面影响。在病例和对照组之间没有发现抑郁症患病率的差异。讨论：与没有出血性疾病的妇女相比，患有VWD的妇女出现月经过多和其他妇科疾病的频率更高。VWD患者的月经对生活活动有负面影响。在这组在HTC治疗VWD的妇女中，抑郁症的患病率没有升高。
Objective: To assess the medical, gynaecological and reproductive experiences of women with von Willebrand's disease (VWD) and to evaluate the impact of VWD on mental health and life activities.Methods: A total of 102 women with VWD who were registered in haemophilia treatment Centres (HTCs) in the United States and 88 controls were interviewed regarding medical, gynaecological and reproductive history, life activities and symptoms of depression. Symptoms of depression were measured using the Center for Epidemiological Studies Depression Scale (CES-D).Results: Excessive bleeding symptoms were reported in 74% of VWD cases compared with 6% of controls. Women with VWD had a higher prevalence of menorrhagia, excessive postpartum bleeding, other gynaecological conditions, arthritis and migraine headaches than did controls. More VWD cases than controls reported that menstruation had a negative impact on overall life activities. No difference in the prevalence of depression was found between cases and controls.Discussion: Women with VWD experience menorrhagia and other gynaecological conditions at a higher frequency than women without bleeding disorders. Menstruation in women with VWD has a negative impact on life activities. The prevalence of depression was not elevated in this group of women whose VWD is being managed in an HTC.