Understanding the role of resilience resources, antiretroviral therapy initiation, and HIV-1 RNA suppression among people living with HIV in South Africa: a prospective cohort study
Understanding the role of resilience resources, antiretroviral therapy initiation, and HIV-1 RNA suppression among people living with HIV in South Africa: a prospective cohort study
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DOI：
10.1097/qad.0000000000002175
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发表时间：
2019-06-01
期刊：
影响因子：
3.8
通讯作者：
Bangsberg, David R.
中科院分区：
文献类型：
--
作者：
Katz, Ingrid T.;Bogart, Laura M.;Bangsberg, David R.
目的：未能启动抗逆转录病毒疗法和实现病毒学抑制是联合国90-90-90目标的重大障碍。识别弹性资源，或可修改的力量为基础的因素，艾滋病毒感染者之间是成功的HIV treatment and prevention.Design的关键：前瞻性队列study.Methods：从2014年7月至2015年7月，500名成年人自愿咨询和艾滋病毒检测谁被诊断为艾滋病毒和ART资格在南非（索韦托和Gugulethu）进行了登记和调查。Logistic回归模型评估了在自愿咨询和HIV检测后6个月内开始ART治疗的毒力相关预测因素，以及在9个月内HIV-1血浆RNA抑制，调整了社会人口学因素。
Objective: Failure to initiate antiretroviral therapy (ART) and achieve virologic suppression are significant barriers to the United Nations 90-90-90 goals. Identifying resilience resources, or modifiable strength-based factors, among people living with HIV is critical for successful HIV treatment and prevention.Design: Prospective cohort study.Methods: From July 2014 to July 2015, 500 adults presenting for voluntary counseling and HIV testing who were diagnosed with HIV and were ART-eligible in South Africa (Soweto and Gugulethu) were enrolled and surveyed. Logistic regression models assessed resilience-related predictors of ART initiation within 6 months of voluntary counseling and HIV testing for HIV, and HIV-1 plasma RNA suppression within 9 months, adjusting for sociodemographic factors.Results: Within 6 months, 62% initiated ART, and within 9 months, 25% had evidence of an undetectable HIV-1 plasma RNA (