Reproductive factors and risk of uterine fibroids
Reproductive factors and risk of uterine fibroids
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DOI：
10.1097/00001648-199607000-00018
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发表时间：
1996-07-01
期刊：
影响因子：
5.4
通讯作者：
Guarnerio, P
中科院分区：
文献类型：
--
作者：
Parazzini, F;Negri, E;Guarnerio, P
我们使用病例对照研究的数据分析了生育史和子宫肌瘤风险之间的关系。病例为621例经组织学确诊为子宫肌瘤的妇女。对照组为1051名未行子宫切除术的患者。与未产妇相比，产妇患子宫肌瘤的相对危险度(RR)为0.5[95%可信区间(CI)=0.4-0.6]，且风险随出生次数的增加而下降。子宫肌瘤的风险也随着人工流产次数的增加而降低(报告一次或两次或两次以上人工流产的妇女的RR分别为0.8和0.6)。24例(3.9%)和19例对照(1.8%)有不孕史(RR=2.0；95%CI=1.1~3.7)。
We analyzed the relation between reproductive history and risk of uterine fibroids using data from a case-control study. Cases were 621 women with histologically confirmed diagnosis of uterine fibroids. Controls were 1,051 nonhysterectomized patients. Compared with nulliparae, parous women had a relative risk (RR) of fibroids of 0.5 [95% confidence interval (CI) = 0.4-0.6], and the risk declined with number of births. The risk of fibroids also decreased with number of induced abortions (RR = 0.8 and 0.6 for women reporting one or two or more abortions, respectively). A total of 24 cases (3.9%) and 19 controls (1.8%) reported a history of infertility (RR = 2.0; 95% Cl = 1.1-3.7).