A MATHEMATICAL EVALUATION OF THE ALVEOLAR AMPLITUDE RESPONSE TECHNIQUE
A MATHEMATICAL EVALUATION OF THE ALVEOLAR AMPLITUDE RESPONSE TECHNIQUE
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DOI：
10.1016/0034-5687(95)00038-f
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发表时间：
1995-10-01
期刊：
影响因子：
--
通讯作者：
HAHN, CEW
中科院分区：
文献类型：
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作者：
GAVAGHAN, DJ;HAHN, CEW
研究了用于测量肺容量和灌注的强制正弦波肺泡振幅响应技术（AART）的基本数学模型。利用数值技术，我们能够评估Zwart等人介绍的原始技术中隐含的几个假设的影响，J.Appl.Physiol.41：419-429，1976，并由其他几位工作者开发。特别是，我们能够表明，AART适用于比最初建议的溶解度范围更广的气体，使其能够与临床上更可接受的试剂（如一氧化二氮）一起使用。此外，我们能够表明，再循环时间的影响可能是非常小的使用数字为标准man.A最小二乘参数恢复技术被证明是非常强大的模拟测量误差，并用于量化的建模假设的影响。
The underlying mathematical model of the forcing sinewave alveolar amplitude response technique (AART) for measuring lung volume and perfusion is investigated. Making use of numerical techniques, we are able to evaluate the effects of several assumptions which are implicit in the original technique introduced by Zwart et al., J. Appl. Physiol. 41: 419-429, 1976, and developed by several other workers. In particular we are able to show that AART is appropriate for gases of a wider range of solubilities than originally suggested, allowing it to be used with agents, such as nitrous oxide, which are more clinically acceptable. In addition, we are able to show that the effects of recirculation times are likely to be very small using figures for standard man. A least squares parameter recovery technique proves to be very robust to simulated measurement errors and is used to quantify the effects of the modelling assumptions.